ID A0A3B4VI38_SERDU Unreviewed; 1282 AA.
AC A0A3B4VI38;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Insulin receptor substrate 1-B-like {ECO:0000313|Ensembl:ENSSDUP00000029460.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000029460.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000029460.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSSDUT00000029959.1; ENSSDUP00000029460.1; ENSSDUG00000021213.1.
DR GeneTree; ENSGT00940000166370; -.
DR OrthoDB; 4212441at2759; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF8; INSULIN RECEPTOR SUBSTRATE 3; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 13..115
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 138..242
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 240..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1282 AA; 134091 MW; 979B70CF4E459716 CRC64;
MDNQAGEQFS CEDVRKSGYL RKQKSMHRRY FVLRAASERG PARLEYYESE KKFRGKAPVP
KKAVALETCF NINKRADSKN KHMIVLYTRA ESFAIAAENE ADQDEWYQAM VDLQCKSKNP
TDSGAAGDYG VPNPGPAFKE VWQVKVWPKG LGQAKNLVGI YRLCLTDKTV NFVKLNSDAA
AVVLQLMNVR RCGHSENFFF VEVGRSAVTG PGEFWMQVDD SVVAQNMHET LLEAMKALSE
EFRQRSKSQS NSGPGGGATA SNPISVPSRR HHPNPPPSQV GFTRRPRTEP PGGSNGAAGG
SSANASPTPR HSFPRSRTAS DGGKGDDGIA GTTPLQGPSS SPSTNGSCST TPILRSKSVR
SAPTTAAKTP LGLMRSISTP APSPAPSLSS SSGHGSEFGG VTSSTGAGPG SGAYSRVPAH
RASVSGSPSD YGSSDEYGSS PGDHTLLPSP SLPGSSVGSV SSQSLGDEGA NYILMGQRSS
SGGGSNQGSL TSSSLPAPGT PACGSQPQTR RVLRRSSSRE CEAERRLLSK RASLPPMTLE
RLAPRQRRAE EPADEDSADY AIMSRSTSRE SFTSISSSMQ RESVMGAGSA GGGGGYLDVA
GEFKSEGSGG AGGSVDLGVD NGYMSMLPGV TQPPVSLSQS LAVSVPDSDS KPTDDYMAMT
PNNSVSPPQQ IRPPPTSDGY MIMSPNSSCS PDQRGGLSGG AWVGSGSADS RAGSDYMNMS
PISARSVNGS PPPPDHTGHL ETSSQQQAPK MVYSYYSLPR SYKHNPSAGH FDDGPGRGRR
PNGNCSRGMG GGRTMGGRQE QQAAGNSVVG RHLSLSSSSY SSSSASSESL GESEERATQA
VSTTAGGAKS KDGSKLQQRR GSAGLSKQGS HSRSRPVSLF VDVSKANTLP RVRENPLPPE
PKSPGEYVSI EFKGEKCSQT MVGGGRGRGL RHGLSLPHCS SSQHPQHRPT SCLGNFVPLS
RSPSAPITPP AASEYVNMDL GPSPSPSPLS LTPLVFPSFH TPPTPPTLAH APKACDEGTT
GPREEGAEVA NAPLRKSRES APSVTESESP TSCGDYTEMA FSLNNNTVPR SSSSVSPKAP
SPTRTDPSVP VLSRGLDFPL AKPGLNPDHG AKVIRADPQG RRRHCSETFL ASPSLPTSNS
TSSSSTASLF PEHAQAVARR LGFENMLWGN GAVTDTPTQC PLPGQQSLPS NTQTSSTEQG
LNYIDLDLVN KESPHLGLDG PSGSQAPSRL FSVLGGGSGI GGVGAAVSSS SSSSLNTYAS
IDFYKSEELR THQNGSKEGT EC
//
