ID   A0A3B4VKL1_SERDU        Unreviewed;       532 AA.
AC   A0A3B4VKL1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Nuclear receptor subfamily 2 group C member 1 {ECO:0000313|Ensembl:ENSSDUP00000031109.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000031109.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000031109.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC       {ECO:0000256|ARBA:ARBA00004322}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily. {ECO:0000256|ARBA:ARBA00006421}.
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DR   AlphaFoldDB; A0A3B4VKL1; -.
DR   Ensembl; ENSSDUT00000031646.1; ENSSDUP00000031109.1; ENSSDUG00000022371.1.
DR   GeneTree; ENSGT00940000158165; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd06967; NR_DBD_TR2_like; 1.
DR   CDD; cd06952; NR_LBD_TR2_like; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR048245; NR2C1/2-like_DBD.
DR   InterPro; IPR048246; NR2C1/2-like_LBD.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24083:SF49; NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 1; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004334};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004334};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU004334};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT   DOMAIN          39..114
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          277..520
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
SQ   SEQUENCE   532 AA;  58900 MW;  4A8BCE80CE9633D8 CRC64;
     MDGQTQRIQL VSADNNMALG HRIQFVTEGS DQSIVKPVVE YCVVCGDKAS GRHYGAVSCE
     GCKGFFKRSI RKNLVYTCRG SGECAINKLH RNRCQYCRLQ RCIALGMKQD SVQCERKPVE
     VTTREKSVNC AASTEKIYIR KNLCSPLAAT PTFVSDKETA RSTSLLESSM LLNIQQPFSK
     LENTILIPAS PDKDDHSQGD LGTLANVVTS LAHLNKTREA SDGGNDLMGV ETLSNGDSSM
     TDIQGDEQTA SDITRAFDTL AKVLHPGDGS AADSLEATMQ LMSGDQSGPV VELEGPLLSD
     SHIPFKLMMP LPVPEYLNVN YICESASRLL FLSMHWARSI PAFQTLGGQD NDINLMKACW
     NELFALGLAQ CSNVMNVGTI LSAIINHLQT SLQEDKLSPE RVKLVMEHIW RMQEFCNSMS
     KLTPDSYEYA YLKAIVLFSP DHPGIDNTPQ IERFQEKAYM ELQDYVTRTY PEDSYRLSKL
     LLRLPALRLI SAAVTEELFF AGLIGNVQID SIIPYILKME STDYNSQAVS GV
//