ID A0A3B4VLZ0_SERDU Unreviewed; 476 AA.
AC A0A3B4VLZ0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=GDNF family receptor alpha-1 {ECO:0000256|PIRNR:PIRNR038071};
DE Short=GDNF receptor alpha-1 {ECO:0000256|PIRNR:PIRNR038071};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000030745.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000030745.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for GDNF. Mediates the GDNF-induced
CC autophosphorylation and activation of the RET receptor.
CC {ECO:0000256|PIRNR:PIRNR038071}.
CC -!- SUBUNIT: 2 molecules of GDNFR-alpha are thought to form a complex with
CC the disulfide-linked GDNF dimer and with 2 molecules of RET.
CC {ECO:0000256|PIRNR:PIRNR038071}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961, ECO:0000256|PIRNR:PIRNR038071}.
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DR AlphaFoldDB; A0A3B4VLZ0; -.
DR Ensembl; ENSSDUT00000031280.1; ENSSDUP00000030745.1; ENSSDUG00000022132.1.
DR GeneTree; ENSGT00940000155560; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR PANTHER; PTHR10269:SF3; GDNF FAMILY RECEPTOR ALPHA-1; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR038071};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038071};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR038071};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 21..103
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 142..225
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 235..329
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
SQ SEQUENCE 476 AA; 52998 MW; B2409495ED474EBD CRC64;
LIISAIYELS GAASRSARLD CVKASEQCLK EYSCSTKYRT MRQCVAGRES NFSAVTGPEA
QGECRSAIDA MKQSPLYNCR CRRGMKKEKN CLRIFWSIFQ SLQGNDLLEY SPYEPVNSRL
SDIFRLAPII AVEPASTKEN NCLNAAKACN LNDTCKKYRS AYINPCTSRV SASEVCNKRK
CHKALRQFFD KVPTKYSYGM LFCSCPVVDQ TACAERRRQT IVPVCSYEDK DKPNCLSLQN
TCKTNYICRS RLADFISNCQ PEARSISGCL RENYADCLLS YSGLIGTVMT PNYVRSLGIS
LSPWCDCSSS GNSKPDCDKF AEFFTNNRCL RNAIQAFGNG TDVGVWQPQP PIQPTIVEPS
ITRRGKERTS NAMDALTHMT KLDLDGDSLY HACGTLQVKK KDTFQSIFSL ILSLCIIVTL
YGLFPQNHQL DESSDSNAIA RSSPAELTCL HPSSMLLALV IGFTPTVLPL QSFYLL
//
