ID A0A3B4VR23_SERDU Unreviewed; 359 AA.
AC A0A3B4VR23;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Perforin-1-like {ECO:0000313|Ensembl:ENSSDUP00000033099.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000033099.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000033099.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3B4VR23; -.
DR Ensembl; ENSSDUT00000033663.1; ENSSDUP00000033099.1; ENSSDUG00000023773.1.
DR GeneTree; ENSGT00990000204057; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR PANTHER; PTHR46096:SF1; ZGC:163021 PROTEIN; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..359
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017452674"
FT DOMAIN 1..285
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
SQ SEQUENCE 359 AA; 40503 MW; B29797A3014C6BDA CRC64;
TERLCLDCCL LLFLSHHSLV LSCEVTAECK SAPFVPGYNL VGEGFDVKFA GLEVGGTRST
AYVFATDRSK EDHYTFSTHR VSCSHYSYRV SDRPPLSYEL SRDLANLPSS YSDSTKTQYR
RIIETYGTHY IRQVHLGGRF RRVTAARTCL SRLNGLSSSM VHSCLSQGIN VGLGKIKLSS
NQKYCSKVLQ NQGISTLFSS GLHQHYTEVV GGKGWVGEFA LTRNDSVGYR NWLKTLKDLP
EVVQYSLRPL YELVPNTTKK QGLKVAIEQY LKDHGIKSST TQPYCGWHDP NLDSSCCPKQ
ASKGRLVVTI VRAWGLKGDR WGRTEGYAKM WYGSIYRKTR MIRSNSPRWN ARYDLGKVS
//
