ID A0A3B4W9K1_SERLL Unreviewed; 5550 AA.
AC A0A3B4W9K1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Dystonin {ECO:0000313|Ensembl:ENSSLDP00000000466.1};
GN Name=DST {ECO:0000313|Ensembl:ENSSLDP00000000466.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000000466.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000000466.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSSLDT00000000511.1; ENSSLDP00000000466.1; ENSSLDG00000000465.1.
DR GeneTree; ENSGT00940000155008; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21236; CH_DYST_rpt1; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 18.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 27.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169:SF24; DYSTONIN; 1.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 2.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 21.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00150; SPEC; 35.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 28.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 34..137
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 150..254
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 5107..5142
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5143..5178
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5183..5300
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 1701..1750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5304..5325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5347..5433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5462..5550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 11..38
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 742..769
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1100..1137
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1216..1243
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1513..1599
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1630..1685
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1800..1841
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2167..2197
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2461..2495
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2687..2717
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2975..3042
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3193..3220
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3447..3507
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4104..4175
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4356..4383
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4865..4892
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 5310..5325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5358..5429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5464..5486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5493..5542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5550 AA; 631629 MW; 45D34FC1C6CEEBE2 CRC64;
MAQYAPQAYV LSDEQEYLQA YEDVLEKYKD ERDRVQKKTF TKWINQHLLK VRKHINDLYE
DLRDGHNLIS LLEVLSGDTL PRERGRMRFH RLQNVQIALD YLKRRQVKLV NIRNDDITDG
NPKLTLGLIW TIILHFQISE IHVTGESEDM TAKERLLLWS KQITDGYVGV RCENFTTSWR
DGRLFNAIIH KYRPDLVDMS RVSTQTNRSN LEHAFGVAEQ LGVARLLDPE DVDVQSPDEK
SVITYVSTLY DAFPKVPDGV EGINPNDVDI KWVEYQNMIK YLSQWIKHNV AIMSDRSFPN
SPVELKALYT QYLQFKEHEI PLKENEKTKI KNLYKMLEMW IEFGRIQLPP GHHPNDVEKE
WGKLIVAMLE REKSLRPEVE RLEMLQQIAN RVQRDCVNGE DKLALARTAL QSDAKRLESG
IQFLHEAEIA GYLLECENIL RQQVVDIQIL LDGKFPFADQ LVQRVSKLRD DLLTLRAECS
SVYSKGRTLT TEQTKMMISG ITQSLNSGFS QNISTNLTPA LTPALTPGGL GTPGSTFTSS
LTPCLTPSLT PTLTPGLQPA SVQSYMGGGG GMDPGSLRHL KHMQIRKPLQ KSSLADPNMT
EEEVNMKYVQ DLLNWVEEMQ VQLDRSEWGS DLPSVELHLE NHKSVHRAIE EFQMSLKDAK
LSEIQMTIPL KLTYSDKLNT LEKQYERLLS CSRERQSHLE SLHDFVSQAT QELIWLNEKE
EEEVAFDWSD RNSNISKKRD YHADLMRELD EKEDTIKSVQ DKAERLMHKN HPAKLTIEAY
RAAMQTQWSW ILQLCSCVEQ HLKENAVYFE FFSDAKESID YLKSLQDAIQ RKYSCDRTSS
LHRLEDLIQE SMDEKEQLLQ YRSTVAGLVG RAKNIVQLRP RNPGSPVRSS LPVKAICDYR
QIEITIYKED ECVLANNSHR AKWKIINPAG NEAMVPSVCF TVPPPNKEAV DMATRTEQLY
QNVLALWHHS HINMKSVVSW HYLMADIRAI RNWNVASIKT MLPGEHQQVL SNLQSHFDEF
LEDSEESEVF TVADCAQLER DVAACKDYYQ ELLRSAEREE HEESVYNNYI SEIRNFRMHL
EAHEEHLIRQ IRTPLERDDL EQSLQRITEH ERKTAELNKL KEDLDVMKEK CELFLRQAAG
SPSVPTLSSE LTVLVQSMSQ VYSMSSIYMD KLKTVSLVVK HSQSAEALVK AYESKLYEED
AMNSDVKSIE TVISTLKQWR TEIDEQQEVF HDMEDELQKA RVISDRMFKA HNERDFDLDW
HKEKADQLSE RWQNIHSQID SRLRDLDGIN KSLKHYRDSY SSLDEWVTEM EEAQRKAQEN
KPEDSKALAE LLNKQKVLVA EIEQKQSRMD ECQKYSEQYS SAIKDYELQL MTFRAMVDSQ
HKSPLKKRRM QSSSDAIQQE FMDLRTRYTA LVTLMTHYVK FASETLKRTE EEERSVDEEK
REHGDKVSKL LHWMSNVKQT LNNDGNALKD SNANKPQVSV EEMVTKKEQI AEALRATQMM
LNKHSDKMTG EEREKAQEQL KALNQAYNEL SQQCSDQTTS AEESLLERHK EFAEKLEEVC
DNLTLTENRL IGHQQQADNA ECVTDLQQYQ QEHQALQNDV LTNASALNEV ITSTKKFLEE
NRNKLTPDQI ATIESKLEEA KSKAKLINQR AEESRKDLEK VVTTAIKQES EKAAAVEQLE
ESKNKIEGLL EWISNIGNEN EDQTDRISKE NGNLPEETSA KGLIGDDDDA NGNALQTTEK
DFGRETSDKN DASLDLDKQY ERVKARHQEI LSQQQDLIMA TQSAQALLDK QANVLSPEEK
EKLQKNIQEL KGRYEASLTQ AEQQMKQVQC VQEELKKFQD DCEEFEGWLD QAEGEIEELG
APTGSLNILS DKLQRQKSFS EDVISHKGDL RFITISGQKV LDVAKACGVG DPAAKNALLN
VDTSGTCSAV KDKLDSAASR YKTLHSQCNQ LGNNLKDVVD KYKKYDDSSA GLLKWLTNSE
EEARKQQSEA IAADPQTLQK QLEETKALQS QMTGHQTAID TLRKTAECLI TSEGDLLSNL
DEIQETVDDI VERYDNVSKS VSDRNEKLQI TLTRSMSVQD GLDEMMGWME GVEASVQEKG
QIPLDSASIG DILSKEAALE QDIASRQSSI SAMKAKVKKF AETADPSAAA LLQSTMDALS
QRFSDACDKH KQKVSQLEQL KEKVEEFETV ADKVQQFVVK RTQDLQETDG PGKTFNELSE
LMQSTKAEMA EHAGDLEKLH TLSKELSEIS PDGNQAQIQS KMDDLSNIFT TFKDTVKEKE
EEVSSCQDQL GEFRSAASTL TKWLEETNDK VPAVQPSSSE KSLETDLQIV TGLLDEWISK
GPAVQDMNSK GSELCSLITF LTSPAKTKTQ NKSALTNGGG PASHSYLTNK ELMIIQQNMS
FVNEGYASLG ETLKGRAAEL STSVQEMKQA QKETEDMLTW LKDKKETAAS WNNAATEKDA
VKTQLEQQKA FEDDMKQKQE QLQKLREKLL DLIKTHPNSP EAAKWKQMLA EIDAAWADIS
GSVEERKQHL EESNKNLDIF QTTELQLGQW LSEKELMMSV LGPLSIDPNM LKMQKQQVQI
LQNEFKSRKP QYEQLEEAAS AILSSSGNQD PSSGKLVREQ LAAVTQKWQG LTGQLDQRDG
LIDQAAVKTG QFQELLRSLS QTATQLESQL TNHQGHSTQP DAVKMQLEDV QNISAQLREE
RKKLKEAEAI NTELTAMVTE DYLKADLARQ LESVSKPFKQ LEEKAAKKIE QLNSTFASSQ
QFHQTSKDFQ SWLGEKLQDQ SQPQPISAKV DILQQTMEEH SKLQEALSEH EEAYNTIIGE
GEMLLQKTDG AEKLALQGQL TTLSSNWEEV KKGSVEHADK LQTALQRSRK YQEHAEKLSS
WIQECEAGEG RVKLTVDPVA VESSISQVKA LQKDVDKHRG MVEQLNAAAD SLLEVANTDT
KAIKEEKASI GKRVDNVVEG LQSKRDSLEK ISHVVKEFND AYKEAKGQLE GAKKQVDAYE
SQGVQGHSNK NLTNMKAQHK SLEGMQNQVE HLKSLAKDLV VDVPDADGVT DLLLQADSIE
KDYGSMTEKL EETCQVLEGK LQGIGQFQNS IRDMFTHFTD LDDELDSMAP VDLELATLKE
QQDSIQSFVA KLQELMANTA NAGDSCKKML ETETSPDLLG LKRDLDALSK QCGKLLDRAK
GREVQVQSTL TKIEELYGKL HQMEDKLSRA EDKEASQEAV GMETDVINQQ LEAFKAFQKD
DIDPLQTQLQ DINSLGQGLI QNATKGTSIK KLEDDLEGVN TKWNTLNKKI AERSAQLHEA
LLHCGRFQDA LESLLSWLTD TEELMANQKP PSAEFKVVKA QIQEQKLLQR LLDDRKPTVE
LIKKEGGKVA ELAESVDKEK VAKEIECLGQ RWDALLKKAE NRHKQLESIL VVTQQFHETL
EPLSEWLSAT EKHLANSEPI GTETSKLEDQ ISQHKALEEE IMNHSKDLLH AVSLGQMLKA
VSSVDEKEFV QSKLDATQAR YIELQERCRR KAEMLQQALA NAQLFGEDEV ALMNWLNEVH
TRLGEVSVED YKLDVLEKQL ADQRALQSDI DLRKKNVDQA ISNGMELLKQ TTGDEVVIIQ
GKLDGIKAKY AEINSMSDNV LKTLERVLSL SSKLQHTHED LSSWLEKTEA EINAFDGQEP
VGEQLIHAQS RQKALLKETK DQKPVMDKMN ELSGSLLDLI PWHTREGLDK LVTEDNERYR
AVCDTVTQQV DQINADILKS QQFEQAADSE LSWLTEAERK LLSMGEIRLE QDQNTAQLQA
QKIFSMDIMR HKDAVDEILK TGKAIMNSKN PEEKEIFKAK TQTLLEKYGV VSQLNSERCL
QLERAHSLAS QFWETYEEMW PWLQETMSSF SQLPPPAIEY ETLRQQQEEL RQMRELIAEH
KPHIDKMNKT GPQLLELSPV EGVPIREKYT TSDQLYSQLK ADVKQRAATL DEAISKSTQF
HDKIDPMLES LERIAERLRQ PPSISVEVDK IREQITENKA VSVDLEKLQP SYETLRQRGE
EMIARSEGAD KDISAKAVQD KLDQMVFLWN DIQALLEERE AKLLDVMDLA DKFWCDHCAL
IVTIKDSQDL LRELEEPGVD PSVVKQQQEF VEGFKEEIDG LQEELDVVQN QGAELMTACG
EPDKPVIKKS IDEVNSAWEN LNKTWKERVE RLEEAMQAAV QFQDGLQGMF DWVDILDSKL
DSMSPVGTDL ETVKQQIVEL KEFKGEAYQL QIEMERLNHQ AGLLLKKVTE EADRSAIQEP
MSELKMLWDN LDEKIISRQH KLEGGLLALG QFQHALDELL AWMSHTEELL NEQRKAGGDP
KAIEIELAKH HVLKIDVLAH KATVETVNKA GNDLVESSAG EEASSLQTKL ENLNQRWKAI
QEKTDQRKQQ LESALVQAQG FHGEIEDMQQ WLKDTERQLL ASKAVGGLPD TAREQLNAHL
ELCSALEAKE ELYRELLNKG QQLLMLAPEG PDSNTEQDLA NLKEKWEAVQ GKVAERKVKL
EEALTLATDF HNSLQDFINW LTQAEQTLNM VSPASLILET IMFQIDEHKM FVTEVNSHRE
HIIELDKTGT HLKYFSQKQD VVLIKNLLLS VQGRWEKLVQ RSVERGRLLD DTRKRAKQFH
ETWNKLMEWL DESEKALDSE VEIANDPDKI KTQLAQHKEF QKALGSKHSV YDTTARTGRS
LKDKTSLQDD NQKLDDMLSE LRDKWDTVCG KSIERQNKLE EALLFSGQFT DALQALIDWL
YRVEPQMAED QPVHGDIDLV LNLIDNHKVF QKELGKRTVS VQALKRSARE LIDSSHDDSS
WVKVQMQELS TRWETVCNLS VSKQARLEQA LCQAEEFHST VHILLEWLAE AEQSLRFHGS
LPDDEEALRA LIEQHKEFMK KLEEKRVALN KATSMGEAIL SICHPDSITT IKHWNTIIKA
RFEEVQAWAR QHQQRLATAL TELLATQELL ENLLTWLQWA ETNLNDKDKE ALPQEIEEVK
GLIAEHQAFM EEMTRKQPDV DKITKTHKRK AAMEPQIQSQ IPVLDKGRAG RKRSPTQTMY
ASATQPPIET KNPRVNLLVT KWQHVWLLAL DRRRKLNDAL DRLEELKEFA NFDFDVWRKR
YMRWMNHKKS RVMDFFRRID KDQDGKVTRQ EFIEGILSSK FPTSRLEMSA VADIFDRDGD
GYIDYYEFVA ALHPNKDAYK PLTDADKIED EVTRQVAKCK CPKRFQVEQI GANKYRFYLG
NQFGLVHCLH DSLIGDETIA NRENQNLTPH LHVAVLESCI LFGDSQQLRL VRILRSTVMV
RVGGGWMALD EFLVKNDPCR VHHHGSKMLR SESNSSITQS PIAKGRTNME LREKFILPEG
TTQVMASFRY RGRRSRPSSR GASPNRSTSS QSCPVPAHHA LTSTPKTPQH ITRNYDKPWL
TNSKPSTPLK SSDSFGSQGS SSESTPVQGS KLRLPGYLSG KGFQSGEEGS LISAAVLKAR
AQTIGDSRRT SSRPGSKAGS RGSSRRGSDA SDFDISDIQS VCSDMSETVG ESSRATPRSA
SRQRGGKPSK IPTPQRRTTP TSKLAKGSKR
//
