ID A0A3B4WAZ3_SERLL Unreviewed; 3958 AA.
AC A0A3B4WAZ3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Fraser extracellular matrix complex subunit 1 {ECO:0000313|Ensembl:ENSSLDP00000000805.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000000805.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000000805.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR STRING; 1841481.ENSSLDP00000000805; -.
DR Ensembl; ENSSLDT00000000866.1; ENSSLDP00000000805.1; ENSSLDG00000000454.1.
DR GeneTree; ENSGT00940000163761; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071711; P:basement membrane organization; IEA:Ensembl.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0010669; P:epithelial structure maintenance; IEA:Ensembl.
DR GO; GO:0033334; P:fin morphogenesis; IEA:Ensembl.
DR CDD; cd00064; FU; 12.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 6.20.200.20; -; 4.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF00093; VWC; 5.
DR SMART; SM00237; Calx_beta; 5.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00261; FU; 14.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS01208; VWFC_1; 4.
DR PROSITE; PS50184; VWFC_2; 6.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3854..3875
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..57
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 62..122
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 126..186
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 188..248
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 252..311
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 330..380
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REPEAT 1064..1169
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1189..1279
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1302..1414
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1439..1535
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1571..1666
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1687..1788
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1811..1912
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1935..2035
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2056..2155
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2177..2269
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2289..2382
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2417..2514
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
SQ SEQUENCE 3958 AA; 435985 MW; 707D9247EE71505A CRC64;
MGQLRNNTSW RPQLCRECTC YSDVAICKPI HCPNPQCDFQ RGELLRIPAK KCCPECVSSS
QGSCQHEGVI YGHDGEWSPS PCSVCICSRG NVSCSTRPCP ALSCPGDQSP FTPAGECCPK
CGRSGESCSW QGVVYRDGEE WKPSLCSRCV CSNGEVQCSV AECQQVACKP HENLVIQPGQ
CCPQCVSNPC LSAGKQHQHG EQWQKNACTT CVCDRGQSKC HTHTCRPVTC DKGHTKVKRA
GQCCDECAAA KGSCLYEGAV RYHGDMWNGT GCEFCSCNRG QVLCRRAECG RVECPQVKRV
HLAGKCCPEC LSLSLSPLFS FPFSLPPLSI FQDMAQWTDG SCRECECRDA RVTCYLRSCP
TCPPGTLAVT QEGRCCPECH QVQCHADCLS CLGTPDHCES CKDPKAFLHL GRCLSACPAG
HYAEGRACAA CQSSCATCSS RWDCQSCGSQ LPLLSADSGQ CLASCPPGSY QHDRTHCRHC
HESCSGCRGP SQRECVACSD AAALLKDGEC VPDCGGGFYS QDGVCHACDS SCASCFPDNP
KCMSCPPGTA LHHGKCITQC PSQHYLDNHN RCRACHSSCA LCWGPSVSQC TLCPGGLLLH
EGQCVEACGE GLYSQDNTCH NCHPSCRSCV GPLASDCLGC LKSEEALLPQ SGHLQHGVCS
AGCPAHAYLD EVQTCRECHP SCRRCTGPSA DNCTSCPSSS GLHDGRCVTS CPQGFFIQDN
QCQACHPSCQ TCSGSSQADC TSCPPPASLQ SGYCRTSCQD EHFLDAVTRE CLNCQRCTAD
LQTGIGSVCL WCKMPRTWLL GDHCVSQCPG GHYSWHGVCM RCHSSCEACS GVGPLSCTSC
PTNSVLLQSG LCAPKCPLGY YDNGHRVCQA CDSQCLTCDM AGVCTSCLDP AKVLLFGECQ
YDSCAHQYYL NTTTRACREC DWSCNACKGP LRTDCLQCME GYVLQDGVCT QGCSPGSYRE
GDRCLGCDEH CVECQGPGQC RRCQPPHATL QGQCVLDCGR NYFLDASSQV CKPCSSDCAL
CDGVGLCRAC RDQTYLIEGY CTPDCGHGYY ADQKTRTCHV NMHPPTLQVN GSLLVPLGGF
APLPPTLLQV KDPDSPSERL IFQLVQSPGN GRLLLLRGEE GEDRERRGKA GRELTRDNTF
TMEELRTGRV RFRHQKDKAR TGEFTLRVAD PQLFSQPETV QVQAVSVQPP RVTALTPLPV
EGLGALATIT KSVLQVDDPD NPADVLVMVI EPPRHGRLTR VHGDRALSRF KLEELSREQI
QYVHNGSEGT EDGAVLQVND GHSYRNVLLQ VHINQKVGWA ADSPLVLSVP VTWVKEGGMV
RLDKRYLKAD YKGVGTDDIV YTILASDGQP KYGEVVLVSM PADGPPEGWR PSLTDDQGFT
STTSFTQQDV NDGTVWYRHF GRGTTSDSFQ FQVSTEAAPA TQSDAQTFTI GVLPQIPGFP
QLAPDCDLQI TALEDRVTEI TPSALSFVDS ETPSEKLIYN ITKPLLPGQG VIEHRDRPYA
AVSHFTQADV NNGKMVYRPP QAPSHLQELY QYSFIGLPES LSVYFTVSDG EHTTPEMDFA
VLLLSNHQQP PVFQVLDPLL EVSLGGQAAI GGQQLAVSDA DTAPDELEFE LVEAPIHGEL
IKTDGNTHTS MTSGDIFTFS DITRNVLLYR HAGLSARDDA ITFSVSDGIS MATTVVQVSV
LGAGGDGPQR DPAATLSLEV GEKSSTVIRR SHLAYTDDPS PDDQIRIQLV SVPMYGILTR
SQSQQEHQEL REYSSFTMED INKHRIRYIT SLETGSQPVT DIFHFVVYDG DNNRLDNQMC
TITITSAPRQ PPAVTVRSGI KVQEGGRVQL STNHIIVSDL DTPGKDLLVW LVSPPKYGFI
ENTNRGSVGG SRVVTPDVPF SVEDLTSDHI FYVQDGQHEA QAERDVFSFY ISDGHSQTEA
FNVEIDIQVT YKEDRRPVVS VSSIHVEENS GVVITNSSLS VHDQDTPENE ILITIIRIPS
YGKLRRRQFY SQPLENGRVL TQGSTFTYQD ILDQLLVYTP EIVSGGADEM AFTLTDGIHT
HTGRLEFTMD VRKSEGPRLT VNRGLQLPAG SSSKITEQNL KGTDMDSDSL KLRYILTKDL
PAGKLQLSRS ERVEKVSVKG PVQSFTQEDV NKGLLQYSHE KGEKGGSLFF KFNLVDPEGN
KLIDQSFFIS VLEDRLPPSV VVNKGLVLDE NSMKKLTTLQ LSASDQDSEP GELIYRITKQ
TGLGHLEHVA SPGTRISTFT QADLASRSIQ YVHTSEEEKH ADQFSFTVSD GTNEVAQTFY
ITIKPVDDSL PLLQVPGMRV QEGVRKTITE FELKATDADT EAESIVFTIV QAPRHGTIER
TGNGQHYRQT SSFTMDDIYQ NRISYNHDGS NSLKDRFTFS VADGTNLLFM VEEGGKEIVT
AAPQKFKIDI LPVDDGTPRI VTNLGLQWLE YMDTKATNLI TKKELLTTDP DTDDGQLVYE
ITTEPKHGFL ESKLKPGNPI ATFTQADINL GLIRYVLHQE NVQETMDNFK FLVKDSKPNV
VSDNVFHIQW SLISFEHKSY NVSEKAATVA VTVKRTGNLN QYAIVLCRTE QGSATSTGSV
GSRPGQQDYV EYAGQVQFDE REDTKVCTIV ISDDKVFEGT ESFHVELSMP VYALLGGNTR
AIVNINDTED EPTLQFDKKT YHVNESTGLI HVPIERKGDA SSTVSALCYT VAKSAQGSSL
HALESGSDYK SRGMTSDNRV LFGPGVSMTT CDIKLIDDSE YELSEEFELV LSDASDNARM
GDVTVAKVVI DGPNDASTVS LGNATFTFSE DAGTIEIPVL RHGSDLSSLT SVWCATRPSD
PPSASPGVDY IPSSKKVEFK PGKTEETCSL TIMDDVQNPS IEGSESFVVF LSSPQGAVLQ
EPYEANVVIT DTFQDIPSMQ FEKSVYTVKE KDSVLHIPII RTGDLSFKSS VRCFTRTMSA
MVMDDFEERR NADESRITFL KGEKVKNCTV HINDDSVFEP EEEFQVHLGT PLGDHWSGAM
VGVNDIVAIT ITNDEDAPTI EFEQASYQVR EPPGPDGIEV LNIKVIRRGD LDRTSKIRCS
TRDGSAQSGV DYNPKSRVLK YTPGMDHILF KVEILSNEDR EWHESFSLVL GPDDPVEAVL
GEITMATVTI LDQEAAGSLI LPAPPIVVSL ADYDHVQEVI KEGSKKTPSP GYPLVCVTPC
DPHYPKYSVM RERCEEAGIN QTQVHFSWEV AAPTDTNGAR SPFETVTDTT PYTSVNHMVL
DSIYFSRRFH VRCVAQARDK AGHLGTPLRS NIATIGTEGS ICHTPVTTGT ARGFQAQSFI
ATLKYLDVKH KEHPNRIHIS VQIPHQDGML PLVSTMPLHN LHFLLSESIY RQQHVCSNLV
TLKDLQGLSE SGFLDDVSYD SISLGPGYDR PYQFNPNVRE AKSIQLYKHL NLKSCIWTFD
AYYDMTELID VCSGSVTADF QVRDSAQSFL TVQVPLYVSY IYVTAPRGWA SLEHHTEMEF
SFFYDTVLWR TGIQTDSVLS ARLQIIRIYI REDGRLVIEF KTHAKFRGQS GLLFAQTFDS
PYQLWRATSS YSRSDYSGEY TVFLIPCTVQ PTQPWIDPGD KPLSCTAHAP EKFLVPIAFQ
QTNRPVPVVY SLNTEFQLCN NEKVFMMDPA ATDVSMAEMD YKGAFSMGQT LYGRVLWNPE
QNLNAAYKLQ LEKVYLCTGR DGYVPFFDPT GTLYNEGPQY GCIQPNKHLK HRFLLLDRKQ
PDVCDRFFHD VPFEAHLASD LPELQSMTAM PGVDGFTMKV DALYKVEAGH QWYLQVIYVI
SPESRSSPRI QRSVTYQLSR PKRDLVDRSG RLTLDESLIY DNEGDQVKNG TNMKSLRLEA
GPSATFNAHV GSSVGGGVAA VTLLVLVLLA SCFLFRRCRR SAKKKTKKSQ KVYEEYPLNT
KVEVCMDKCV EKNFSTKHCT VRNINILNRN QEANSKAKVK QVNLEVKLHN NLNDGTEV
//
