ID A0A3B4WB31_SERLL Unreviewed; 1195 AA.
AC A0A3B4WB31;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 1 {ECO:0000313|Ensembl:ENSSLDP00000000855.1};
GN Name=RASGRF1 {ECO:0000313|Ensembl:ENSSLDP00000000855.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000000855.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000000855.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4WB31; -.
DR STRING; 1841481.ENSSLDP00000000855; -.
DR Ensembl; ENSSLDT00000000919.1; ENSSLDP00000000855.1; ENSSLDG00000000687.1.
DR GeneTree; ENSGT00940000157599; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 240..426
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 467..583
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 630..745
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 960..1192
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 708..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 150..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 795..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1195 AA; 136696 MW; B2846308D3731BEA CRC64;
MQKGIRLNDG HVTYLGLLAK KDGTRRGCLS KKSSDNTKWH TKWFALLQNM LFYFENESSS
RPSGLYLLEG CICDRAPSPK PSLSAKECLE KQYYFTVSFT HENQKALELR TEDVKDCDEW
VAAISHASYR NLANEHETLM QKYLHLLQIV ETEKTVAKQL RQQIEDGEIE IERLKSEIAG
LLKDNEKIHA SPAAAPTDDD SEIKKIKKVQ SFLRGWICRR KWKTIIQDYI RSPHAESMRK
RNQVVFSMLD SEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL
KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLD YAKSKLEELS
RIMHDEVSET ENIRKNLAIE RMIVEGCEIL LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG
SLSLKKEGER QCFLFSKHLI ICTRGSGGKL HLTKNGVVSL IDCTLMEDPE GTDDEYKSGQ
DMEHLDFKIV VEPKDSQSFT VILVASSRQE KSAWTSDISQ CIDNIRCNGL MMNAFEDNSK
VTVPQMIKSD SSLYCDDVDI RFSKMMNSCK VLQIRYASVE RLLERLTDLR FLSIDFLNTF
LHSYRVFTTA DVVLDKLITI YKKPISAIPA RSLELFFASS QNSKLLYGEP PSSPRASRKF
SSPPPLAIAK NSSPNRRRKL SLNIPIITGG KALDLAALSC SSNGYASMYS SMSPFSKTTL
DINKLYVASP IASKIPDEGE DKKDKVEESS VNKQDLSVRE ESDNDPNQSD DGDPEASPTK
SPTTPKNVKC KNSSGFPTDQ RNGDKEFVIR RAATNRVLNV LRHWVSKHSP DFESNNELKT
KVIAFLEEVM HDPELLTQER KAAANIIRTL TQEDHGDSQI TLEDVTQLVS VKAEPFESHS
ALEIAEQLTL LDHLVFKVIP YEEFFGQGWM KNDKNEKTPY IMRTTKHFND ISNLIATEIL
HCDDVVTRVA VIEKWVAVAD ICRCLHNYNA VLEITSSLNR SSVFRLKKTW LKVSKQTKAL
IDKLQKLVSS EGRFKNLREA LKNCDPPCVP YLGMYLTDLA FIEEGTPNYT EDNLVNFSKM
RMISHIIREI RQFQQTAYKI DLQPKVAEYL LDRSCVLDEE SMYEASLRIE PKVPN
//
