ID A0A3B4WER5_SERLL Unreviewed; 219 AA.
AC A0A3B4WER5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 7 {ECO:0000256|RuleBase:RU364060};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000002886.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000002886.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|ARBA:ARBA00025687}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364060}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364060}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC {ECO:0000256|ARBA:ARBA00009994, ECO:0000256|RuleBase:RU364060}.
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DR AlphaFoldDB; A0A3B4WER5; -.
DR STRING; 1841481.ENSSLDP00000002886; -.
DR Ensembl; ENSSLDT00000002997.1; ENSSLDP00000002886.1; ENSSLDG00000002310.1.
DR GeneTree; ENSGT00940000165241; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 6.10.140.200; -; 1.
DR InterPro; IPR037212; Med7/Med21-like.
DR InterPro; IPR009244; Mediatior_Med7.
DR InterPro; IPR044888; Mediatior_Med7_sf.
DR PANTHER; PTHR15498:SF72; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7; 1.
DR PANTHER; PTHR15498; T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING TIM; 1.
DR Pfam; PF05983; Med7; 1.
DR SUPFAM; SSF140718; Mediator hinge subcomplex-like; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364060};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364060};
KW Transcription {ECO:0000256|RuleBase:RU364060};
KW Transcription regulation {ECO:0000256|RuleBase:RU364060}.
SQ SEQUENCE 219 AA; 25205 MW; A951323520A0F05D CRC64;
MGEPQQVSAL PPPPMQYIKE YTDENIRKGL APKPPPPIRD SYMMFGNQFQ CDDLIIRPLE
SQGIERLHPM QFDHKRELKK LNMSILVNFL DLLDILIKSP GSIKREEKLE DLKLLFVHMH
HLINEYRPHQ ARETLRVMME VQKRQRLETA ERFQKHLERV VEMIQGCLAS LPDDLPQMEG
PDGVGDGTRG VSAASVPTSK RDKIWDKDAA MCSIIDEIA
//