ID A0A3B4WG07_SERLL Unreviewed; 513 AA.
AC A0A3B4WG07;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Phosphatidylinositol 4-kinase type 2 {ECO:0000256|RuleBase:RU367084};
DE EC=2.7.1.67 {ECO:0000256|RuleBase:RU367084};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000001442.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000001442.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00036767};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19878;
CC Evidence={ECO:0000256|ARBA:ARBA00036767};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Early endosome
CC membrane {ECO:0000256|ARBA:ARBA00004146}. Endoplasmic reticulum
CC membrane {ECO:0000256|ARBA:ARBA00004586}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}. Membrane
CC {ECO:0000256|RuleBase:RU367084}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU367084}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00008941,
CC ECO:0000256|RuleBase:RU367084}.
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DR AlphaFoldDB; A0A3B4WG07; -.
DR STRING; 1841481.ENSSLDP00000001442; -.
DR Ensembl; ENSSLDT00000001524.1; ENSSLDP00000001442.1; ENSSLDG00000001185.1.
DR GeneTree; ENSGT00390000010434; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR039756; Lsb6/PI4K2.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR PANTHER; PTHR12865:SF6; PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2-BETA; 1.
DR PANTHER; PTHR12865; PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU367084};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|RuleBase:RU367084};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367084};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU367084};
KW Transferase {ECO:0000256|RuleBase:RU367084}.
FT DOMAIN 149..483
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 83..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 513 AA; 57418 MW; 3DDF4549703DAC90 CRC64;
MSECDPTETE TSEPVSLTGA TAESVLESNF HSADPPNVLF DRKQIGLGLS ANPGAAVRIS
DSCESVLTEL ETDGSGEEAL LLPCLAGGSS SPRGVREKRS RRNRHSSSSD KDNLASPGNC
TNSGDFNHFP EDPEFADIIQ RAEQAIENGV FPERISQGSS GSYFVKDPKG KIIGVFKPKS
EEPYGHLNPK WTKYFHKLCC PCCFGRGCLL PNQGYLSEAA ASLVDTKLGL GVVPKTKVVY
LASETFHYSA IDRAKSRGKK YALEKVPKVG RRFHRVGLPP KVGSFQLFVE GYREADYWLR
RFEAEPLPEN IRKQLQSQFE RLVVLDYVIR NTDRGNDNWL IKYEKPGEGG GEGDGQKDSE
WPENCPESCI KIAAIDNGLA FPFKHPDEWR AYPFHWAWLP QAKVAFSQET RDLVLSRLSD
MNFVQDLCED LYEMFKTDKG FDKTMFERQM SVMRGQVLNL TQALKDGKSP IQLVQMPRVV
VERSRSGGQG RVVTLGNAFT QTFHCKRPFF SSW
//
