ID   A0A3B4WMH1_SERLL        Unreviewed;       830 AA.
AC   A0A3B4WMH1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN   Name=AMPD2 {ECO:0000313|Ensembl:ENSSLDP00000002603.1};
OS   Seriola lalandi dorsalis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000002603.1, ECO:0000313|Proteomes:UP000261360};
RN   [1] {ECO:0000313|Ensembl:ENSSLDP00000002603.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|PIRNR:PIRNR001251};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
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DR   AlphaFoldDB; A0A3B4WMH1; -.
DR   STRING; 1841481.ENSSLDP00000002603; -.
DR   Ensembl; ENSSLDT00000002712.1; ENSSLDP00000002603.1; ENSSLDG00000002040.1.
DR   GeneTree; ENSGT00950000183011; -.
DR   OrthoDB; 20951at2759; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000261360; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF3; AMP DEAMINASE 2; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251}.
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   830 AA;  95953 MW;  B683D2CB2A2AA7D2 CRC64;
     MSSNLPPGTT AGAAGAKNKP LSPFRKRGSL QYTASTVDLR GARHLLTSQH SLPGIPVALK
     QSIDLRTSMD GKYKEIAEEL FSRSLAESEM RSAPYEFPED SPIEQLEERR QRLERQISQD
     VKFEPDILLR AKQEFMKTDS ATDLEYMKEQ SQAPDLQERE PVPEREYQRV TISGEEKCGV
     PFTDLLDAAK CVVKALFIRQ KYMGLSLQSF CRTTSRYLQE LSERPLDLDL YEEEIPETTG
     TADATVHPPV SQTHPYENQD PASMPPDMGY GCKMVDGVMH VYTTRSIMEK STELDLPYPD
     LQEYIADMNV MMALIINGPV KSFCYRRLQY LSSKFQMHIL LNEMKELAAQ KKVPHRDFYN
     IRKVDTHIHA SSCMNQKHLL RFIKRAMKKY PKEIVHVERG NGQTLMEVFE SMNLTAFDLS
     VDTLDMHADR NTFHRFDKFN AKYNPIGESI LREIFIKTDN HIEGKYFGHI IKEVMADLEE
     SKYQNVELRL SIYGRSRDEW DKLAKWAVKH QVYSTNVRWL VQVPRLFDVY HTKKQLCNFQ
     EMLENVFMPL FEVTVNPGSH PELHLFLQHV VGFDSVDDES KPEQHIFNLD SPLPVNWTEE
     DNPPYSYYLY YMYANMTVLN HLRRQRGFHT FVLRPHCGEA GPIHHLVSGF MLSENISHGL
     LLRKAPVLQY LYYLAQIGIA MSPLSNNSLF LSYHRNPLPE YLSRGLMVSL STDDPLQFHF
     TKEPLMEEYS IAAQVWKLSS CDMCELARNS VLMSGFSNKV KSYWLGPNYI KEGQESNDIR
     RTNVPDIRVA YRYETMCEEL NLITQAIRTD ELETIEEEGS LCMAAVQAEK
//