ID A0A3B4WNE0_SERLL Unreviewed; 433 AA.
AC A0A3B4WNE0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=StAR-related lipid transfer protein 3 {ECO:0000256|ARBA:ARBA00020514};
DE AltName: Full=START domain-containing protein 3 {ECO:0000256|ARBA:ARBA00032621};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000002818.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000002818.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004107}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the STARD3 family.
CC {ECO:0000256|ARBA:ARBA00010909}.
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DR AlphaFoldDB; A0A3B4WNE0; -.
DR Ensembl; ENSSLDT00000002928.1; ENSSLDP00000002818.1; ENSSLDG00000002205.1.
DR GeneTree; ENSGT00940000159051; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015485; F:cholesterol binding; IEA:InterPro.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR CDD; cd08906; START_STARD3-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR019498; MENTAL.
DR InterPro; IPR000799; StAR-like.
DR InterPro; IPR029867; STARD3_MLN64_C.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR46121:SF2; STAR-RELATED LIPID TRANSFER PROTEIN 3; 1.
DR PANTHER; PTHR46121; STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE; 1.
DR Pfam; PF10457; MENTAL; 2.
DR Pfam; PF01852; START; 1.
DR PRINTS; PR00978; STARPROTEIN.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR PROSITE; PS51439; MENTAL; 1.
DR PROSITE; PS50848; START; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 51..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..198
FT /note="MENTAL"
FT /evidence="ECO:0000259|PROSITE:PS51439"
FT DOMAIN 224..424
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
SQ SEQUENCE 433 AA; 49079 MW; D52D14310D6A4314 CRC64;
MPGGEYGELG GSLPAIASLN ASYSTSLSLP SPYLFVPPAE RRLISDVRRT FCLFVTFDLL
FISLLWIIEL NISSTIWDSL ENEVVRYKFK SSFFDIFLLA VFRFLCLQVG YAAFRLKHWW
VIALLSQNAF GYVLPITSFV VAWLETWFLD FKVLTQEADD ERAYLAVVNA ACERAPMIYP
RAVSDGQFYS PPESVAGSEE DLDEEGLGRR AVTAQEKEYV RLGREAMSVV EQILAQEENW
KFEKNNDMGD SVYTLEIPFH GKTFILKAFM QCQAELVYQE VILQPEKMVQ WNKTVSACQI
LQRVDDNTLV SYDVSAGAAG GVVSARDFVN VRRVERKRDC YLSAGMATEH DAKPPSGRYV
RGENGPGGFV VLKSSSNPSV CTFIWILNTD LKGRLPRYLI HQSLAATMFE FMSHLRQRIA
DLRPSHRSHH HLT
//
