ID A0A3B4WRT8_SERLL Unreviewed; 1196 AA.
AC A0A3B4WRT8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Integrin subunit alpha 1 {ECO:0000313|Ensembl:ENSSLDP00000007634.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000007634.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000007634.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3B4WRT8; -.
DR STRING; 1841481.ENSSLDP00000007634; -.
DR Ensembl; ENSSLDT00000007877.1; ENSSLDP00000007634.1; ENSSLDG00000005952.1.
DR GeneTree; ENSGT00940000157646; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF22; INTEGRIN ALPHA-1; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 20..1196
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5017102725"
FT TRANSMEM 1126..1150
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 24..82
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 157..343
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 354..405
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 465..527
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 544..602
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 606..666
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1196 AA; 133005 MW; 59C94BCA54B0CBC3 CRC64;
GFVKVHQFIL KVLLTRVLSF NVDQKNALSF SGPLEDMFGY TVQQFENSEG KWVLIGSPLS
GQPARRTGDV YKCPVGTGNN TCIKLDLPKN TTFPNVNEVK ENMTMGTTLV TNPNGGFLAC
GPQYGYMCGQ QQYITGVCAN VSSSFQIINS LAPTELDIVM VLDGSNSIFP WSSIIDFLQR
LIGKIDIGPK LSQVGIVSYG ETVTHRVNLS QFDNTRDLLK FVKDLPQQTG FKTMTFLGID
TARKEAFMPE RGARPGVKKV MVIVTDGESH DFHNLDKVIK DCNDDGIERF GIAVLGDYNR
QNKMPEDVQK FIKEIESISS KPLKDHFFNV SDEVALLTIV DALGNKIFAL EATTSNFTSS
FEMEMSQAGF SAHSSKEGVL LGAVGAYDWN GTVIMNTAGE NFIPEKNQFY DPKTEAGYER
LAGYTGYDVQ SASTPHGMLY ITGAPRYNHT GRVVIYRMAG KKNIVVSQIL SGEQIGSYFG
SVLQTVDVDG DSYTDLLLVG APMYMGSERN EQGQVYVYKV NQDGQFKYEF TLKPVNQSCC
TAHSAICTNK NEPCGARFGT AIAAVSDLNL DGFNDVAIGA PFENDHRGAV YIYHGDKTSL
KEKFVQRIPA GGDGEKVKFF GQSIHGVMDL NGDGITDVTI GGLGGASLFW SRDVAELRAN
MTFDPVKINL QQAQYQCEHN GRKSVCVKTE VCFNYTIKSH KRVLNSAAEI RYHLTLDALR
AKARASFIHS DDKNDRRITK TLTIKDKERK CVQETLMMST WLDFRDPLMV SLEFELADED
QGPVLDESLP RSINKTIPLV DCGSDEKCIA DLSLEAEPSV KSMVIKSKMD KIDVKIKVRN
SKDNAYNTKV VLSFTPNINF IKAEPEKECN LNNTKVECAV GYPFLGSNVE VCFSVQYIHQ
TTYNIYTIYM GCRDDSEELA STLNDNTVLI SVPVKYQPGF IFSVRPVDEH IVVKEGEQYA
TVFNDTRMIG EEVNISYTEA GDVVTPPLDL TVTYPQRSPR GNNLLYLTHV TTTRLINPDQ
INPRTITPNP IKETLSVFLL VSNNCSADHD VYCPSFTCTL PEAQTSQVNV TFRVWKPTFI
KGEFSSVHMC VNGTLGIKNT NLFELNSGGR TRHVKIQVSK ESLGGIPIWV IIISILIGLL
ILALVIFALW KVIFPELDCT VFKIFKYQIT MCVKLSLVKF PAQILCDCQE NWQKKM
//
