ID A0A3B4WS81_SERLL Unreviewed; 481 AA.
AC A0A3B4WS81;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=5'-3' exonuclease PLD3 {ECO:0000256|ARBA:ARBA00039647};
DE EC=3.1.16.1 {ECO:0000256|ARBA:ARBA00039059};
DE AltName: Full=Choline phosphatase 3 {ECO:0000256|ARBA:ARBA00042227};
DE AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D3 {ECO:0000256|ARBA:ARBA00043136};
DE AltName: Full=Phospholipase D3 {ECO:0000256|ARBA:ARBA00041681};
GN Name=PLD3 {ECO:0000313|Ensembl:ENSSLDP00000003953.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000003953.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000003953.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 5'- to 3'-direction to yield
CC nucleoside 3'-phosphates.; EC=3.1.16.1;
CC Evidence={ECO:0000256|ARBA:ARBA00035759};
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00037858}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00037858}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004639}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004639}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00037797}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00037797}. Lysosome lumen
CC {ECO:0000256|ARBA:ARBA00004227}.
CC -!- SIMILARITY: Belongs to the phospholipase D family.
CC {ECO:0000256|ARBA:ARBA00008664}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B4WS81; -.
DR STRING; 1841481.ENSSLDP00000003953; -.
DR Ensembl; ENSSLDT00000004088.1; ENSSLDP00000003953.1; ENSSLDG00000003145.1.
DR GeneTree; ENSGT00950000183059; -.
DR OrthoDB; 1203524at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR032803; PLDc_3.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR PANTHER; PTHR10185:SF16; 5'-3' EXONUCLEASE PLD3; 1.
DR PANTHER; PTHR10185; PHOSPHOLIPASE D - RELATED; 1.
DR Pfam; PF13918; PLDc_3; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 188..215
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 402..428
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 481 AA; 54078 MW; 4B251738080108C4 CRC64;
MDITYNKLVD VEWRRQDDRK AQLYSRCVVA LATVATVLLA AMAVYNLLTP RVSSSHTASS
SSIRLPQAES CYDPCEIVLV ESIPEGLEFN SSTTHPSIFQ AWLNLVSEAR SSVDIASFYW
TLTNKDTGTH EPTANQGETI LKKLAELSGK LSVRIAVNRP QESQPQDDLK LLNDSGADIR
TVNMRDLTSG VLHTKFWVVD KKHIYIGSAN MDWRSLTQVK ELGVVVYNCS CLAADLGKIF
EAYWFLGESQ KIPSPWPSSF STLYNKDTPL QLPLNNTPSN VYLSSSPPSF CAAGRTPDIQ
SILSVMEDAQ SFIYIAVMNY LPTMEFSHPK RYWADIDTQL RRVAYERRVK VRLLISCWAS
TQPVMFPFLK SLASVYDPMN KLDIQVRLFV VPANPKQKEI PFARVNHNKY MVTDKIAYIG
TSNWSGDYFV HTAGSALVVN QTASRSPDPT VQSQLKAVFE RDWSSDYSTP VTQNSNLKDF
C
//