ID A0A3B4WX16_SERLL Unreviewed; 1746 AA.
AC A0A3B4WX16;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Adhesion G protein-coupled receptor B2-like {ECO:0000313|Ensembl:ENSSLDP00000008470.1};
GN Name=ADGRB2 {ECO:0000313|Ensembl:ENSSLDP00000008470.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000008470.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000008470.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSSLDT00000008743.1; ENSSLDP00000008470.1; ENSSLDG00000006685.1.
DR GeneTree; ENSGT00940000160103; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd15988; 7tmB2_BAI2; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1746
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017459406"
FT TRANSMEM 924..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 957..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 995..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1028..1046
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1066..1089
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1144..1166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 543..613
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 922..1196
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 307..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1671..1746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1679..1705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1726..1746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1746 AA; 189637 MW; 838884BEF9D931D5 CRC64;
MNTAGGVCLS VLSSLLAVAG ALAAVSALAL APLSALAEAA HGAADGIPRT GAEGAPSPIS
APCSSLVAGV LYGSFSLREL FPSRAPGCSW SLENPDPTKY SLYLRFTRHP VICRTHSPML
LSLDHHLANQ SCPLHLKSAR NQDQEVIDLC GSQSNSDGPY SFLQFDKNFV QLCLTRHPAA
DEPQVTKEVL ELRLVEVLLI NNENSSQFTC GVLCRWFEEC LRTGHNGDQE VSNGDGCGMT
QTGCICPNHN IMAPPIPLLP ETPHSFSNGS LVPDDCCVTE LHSNDAIAIA PRDVRQDPYD
DDLKVKTQRP RSADQPGVFQ AQTGDPAAEE WSQWSVCSLT CGQGWQVRTR SCVSSPYGTL
CSGALRETRM CNNTASCPGE PGITGSVNGL WEEWSSWSLC SVTCGRGSRT RTRKCVNGGV
AVACGRPEIQ TKLCNIAVCP VEGQWLEWGP WSRCSVTCNT GTQQRQRRCS ASVHGWAECK
GPHQESRECT NPSCGGGGNW GSWNHWSLCS KTCDSGWQRR FRMCEGTGVQ GYPCDGSGEE
VRSCNEKKCP APHEICKDEH LLAMSWKRAS AGETVYNKCP TNATGSASRR CMLDNNGVAF
WGPPSFARCV SLEYRYLHLS LREHLAKGQR TLAGEGMSQI VRSLLELLQR RSYYSGDLLF
STEILRNVTD TFKRATYIPA PDDVQKFFQI VSHMLDMENL EKWEDAHQVA PGAALLMRIL
EDFIHLIGEA QKPFQSFLVV TNNLMITIQR EPVSAVSSDI NFPMKGRRGM KDWARTAEDK
LYIPKEVFTV PTEETETDSE STMYYVIGAV LYRTLGVILP MPNPPAVINS KILTVTVRPE
PQPSEPMVVV ELSPLLNGTS DPQCVVWDYG NPEAGAENWG TEGCQTLAST TVHTKCLCSR
ISTYAVLAQQ AKDPDMGPTS MPSVPLMVGC GVSCTALLIL LLIYAAFWRY IRSERSIILV
NFCLSILASN LLILVGQSQT LSKGLCTVTA AFLHFFFLAS FCWVLTEAWQ SYLAVIGKMR
SRLIRKRFLC LGWGLPALVV AVSVGFTRAR GYGTASYCWL SLEGGLLYAF VGPAAVIVLV
NMLIGIVVFN KLMSRDGISD KSKKQRAGVP AEARSRLLLK CSKCGVISST ALSSSTASSA
MASLWSSCVV LPLLALTWMS AVLAITDRRS TLFQVLFAVF DSVQGFVIIT VHCAMRREVQ
DAVRCRMGGC KDDSENSPDS CKNGQKCPNV SYCGQQCGSL RYGTSPCLSG CHPQQLPTSC
HPACQQGCYH SLLRGTNNQG LDYTQALNHA HEHNPILNNT HNHAHNHNHS HNHIGSQPTD
FEKDVDLACQ TERGHPFIFK EVNTCNPATI TGTLSRISLD DEDDPKLAAH QEGGVGVNFS
SLPGNIPPPN LIVQVPPLGG LNELSETPLK KEVNVDQQRQ QGQPRSGAPI YLCTESGLGW
ARPPASSNNS QDGSAGSGGS GGGGGGSGGG GEGDYMVLPR RTVSLKPPAP SSQGGLGLGG
EDKPLNIAVE DPPFPPPPSP LTLHPAESEA YPADFVPSSV GDMNITMNLN RSYGTIKTMP
HGHGHMMAQG SLVHSHGGHM HTHGHSLQLK PGQRPSVRQI LTGGTTVERT RTLPRNLGST
NANTSLSAGS LEKVMHTRKR HSELYHELNH SSKFHTIDRY SRDAAMSTFK REKRWSISSA
GGEKNSSSDK STPEDQSSWD SFKTMTPELS IVPGEQKDRM ELHNKNWDSS SANTPDSSEG
DFQTEV
//
