ID A0A3B4WYH6_SERLL Unreviewed; 925 AA.
AC A0A3B4WYH6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Sodium/calcium exchanger 3-like {ECO:0000313|Ensembl:ENSSLDP00000005798.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000005798.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000005798.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR AlphaFoldDB; A0A3B4WYH6; -.
DR STRING; 1841481.ENSSLDP00000005798; -.
DR Ensembl; ENSSLDT00000005997.1; ENSSLDP00000005798.1; ENSSLDG00000004599.1.
DR GeneTree; ENSGT00940000157547; -.
DR OrthoDB; 462435at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF7; SODIUM_CALCIUM EXCHANGER 3; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..925
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017194896"
FT TRANSMEM 72..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 753..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 859..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 389..488
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 518..618
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 925 AA; 102807 MW; 5D03984EC3FAFC7E CRC64;
MEGSRPVKPG SSACLWLGLV SVAVAFLCTE ARTTPSPLLS PSNATCEGNS KCHAGIILPI
WYPEDPSMGD KIARVIVYFV ALIYMFLGVS IIADRFMAAI EVITSQEREI VIKRPNGETT
TTTIRVWNET VSNLTLMALG SSAPEIMLSV IEVCGHEFKS GELGPSTIVG SAAFNMFVII
GLCVSVIPQG EVRKVKHLRV FFVTAGWSIF AYIWLYMILA VFSPNVVQVW EGLLTLAFFP
ICVLLAWVAD RRLLFYRFMH KKYRTDKHRG VIIETETERS KGIEMDGKMV NSHFMDGGAA
SNLIGLIESK EVDESRRDMI RILKDLKQKH PEKELDQLVE MANYYALSHQ QKSRAFYRIQ
ATRMMTGAGN ILKKHVAEQA KKSASVQEVH VEEPEEYVSR IAFEPAVYQC LENCGAAILT
ITRKGGDINK TIYVDYKTED GSANAGADYE FTEGTVVFKP GEMIKEISIG IIDDDIFEED
EHFFVRLSNL RVLETEDEVL SPNSLPYPKA MLGFPAVATV TILDDDHSGI FTFESSSVHV
SESIGIMEVK VLRTSGARGT VIVPYRTMEG LAKGGGEDFE DTYGELEFKN DETCKLIHVK
VIDDEEYEKN KNFFLELAEP RMVDMSLQKA WLLADDVPDR KLTSDEEEAK RIAEMGKPVL
GEHSKLEVII EESYEFKSTV DKLIKKTNLA LVVGTNSWRD QFMEAITVSA DEDEEDTGEE
RLPSCFDYVM HFLTVFWKVL FACVPPTDYL NGWACFIISI IIIGLLTAVI GDLASHFGCT
IGLKDSVTAV VFVALGTSVP DTFASKVAAV QDTYADASIG NVTGSNAVNV FLGIGMAWSV
AAIYWHMKGK PFVVEAGSLA FSVTLFTIFA FLAISVLLYR RRAHIGGELG GPRGHRLATS
AFFFSLWFLY ILFSSLEAYC HIEGF
//
