ID A0A3B4WZ32_SERLL Unreviewed; 801 AA.
AC A0A3B4WZ32;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Nuclear receptor subfamily 3 group C member 1 {ECO:0000313|Ensembl:ENSSLDP00000009195.1};
GN Name=NR3C1 {ECO:0000313|Ensembl:ENSSLDP00000009195.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000009195.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000009195.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR AlphaFoldDB; A0A3B4WZ32; -.
DR Ensembl; ENSSLDT00000009506.1; ENSSLDP00000009195.1; ENSSLDG00000007270.1.
DR GeneTree; ENSGT00940000156385; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0033993; P:response to lipid; IEA:UniProt.
DR GO; GO:0014070; P:response to organic cyclic compound; IEA:UniProt.
DR CDD; cd07172; NR_DBD_GR_PR; 1.
DR CDD; cd07076; NR_LBD_GR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR48092:SF5; GLUCOCORTICOID RECEPTOR; 1.
DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 444..519
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 548..782
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..278
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 801 AA; 87965 MW; C8A0CC1605049833 CRC64;
MDQGGLKRNG NRDDSLTFGE TGVTVSGDTG DTAGSLLQSA MHLPGSGSLP QPTVAPNGRA
GTKEQGEFGG LFESPQRHAL CEGSDTKEGK MIRMQKRQQQ QHQDIGMFNM EDNVPLLNQS
ISDLSRTSTS VISTSDSSVL GNLPLPDLFP QHIKQEGSFS LEKDLGTYGG HTGAGPCDLD
GSSSRLLEDT EIWQDLDLPS SLPEISDFEL DSEVAHLDNI LHVSSGGGGP EGGLLKETKS
LVGNGGNCTN VNGTDQQHPT HHHQQQQQHH HLLQHQQHPL HHQHQQPPSL LSTVMIKEEK
DPDDSFTHIR TPGVVKQEKQ DGAGFCQSQC LQSGMSSLHG GPLTSPMGVS AGAGFHIKAS
PSSTVGLQDQ KPFGMYSNLL PMGESWARGN RYGESSGIQR ADDGLSSATA LAPFSVSFSS
SSPRTGESSS SAVPGQSKPS GQTHKICLVC SDEASGCHYG VVTCGSCKVF FKRAVEGQHN
YLCAGRNDCI IDKIRRKNCP ACRFRKCLQA GMNLEARKNK KLIKMKVPRP PGSSEPISNM
PVPVIPRCMP QLVPTMLSVL KAIEPEIIYS GYDSTLPDTS SRLMTTLNRL GGQQVISAVK
WAKSLPGFRN LHLDDQMTLL QCSWLFLMSF SLGWRSYEQC NGSMLCFAPD LVINKERMKL
PFMTDQCEQM LKICNEFVRL QVSYDEYLCM KVLLLLSTVP KDGLKSQAVF DEIRMTYIKE
LGKAIVKREE NASQNWQRFY QLTKLLDSMQ EMVEGLLQIC FYTFVNKTLS VEFPEMLAEI
ITNQIPKFKD GSVKPLLFHQ K
//
