ID A0A3B4X1N6_SERLL Unreviewed; 2542 AA.
AC A0A3B4X1N6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 {ECO:0000313|Ensembl:ENSSLDP00000011424.1};
GN Name=HUWE1 {ECO:0000313|Ensembl:ENSSLDP00000011424.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000011424.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000011424.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR Ensembl; ENSSLDT00000011835.1; ENSSLDP00000011424.1; ENSSLDG00000008966.1.
DR GeneTree; ENSGT00940000156319; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd14288; UBA_HUWE1; 1.
DR Gene3D; 3.30.720.50; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR010309; E3_Ub_ligase_DUF908.
DR InterPro; IPR010314; E3_Ub_ligase_DUF913.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041918; UBA_HUWE1.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR018123; WWE-dom_subgr.
DR InterPro; IPR037197; WWE_dom_sf.
DR PANTHER; PTHR11254:SF67; E3 UBIQUITIN-PROTEIN LIGASE HUWE1; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF06012; DUF908; 1.
DR Pfam; PF06025; DUF913; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF02825; WWE; 1.
DR SMART; SM00165; UBA; 1.
DR SMART; SM00678; WWE; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR SUPFAM; SSF117839; WWE domain; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50918; WWE; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1397..1436
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 1682..1761
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT REGION 484..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1335..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1767..1821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2109..2152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2353..2411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2474..2542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1367..1398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1777..1795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2124..2151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2374..2388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2391..2406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2474..2491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2500..2533
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2542 AA; 278850 MW; 2344F3519A011437 CRC64;
MKVDRSKLKK TPTEAPADCR ILIEKLKACS DEQLLVELQH IKTWNIGKCE LYHWVDLLDR
FDGILCDAGQ TVENMSWLLV CDRPDNGQLK ALLLAVLNFT ALLIEYSFSR HLYSSIEHLT
TLLASCDMQV VLSVLNLLYV FSKRSNYITR LGSDKRTPLL ARLQHLAESW GGKENGFGLA
ECCRDLPMTK YPPSATTLHF EFYAEPGPEV KVERKTSSNT LHYIHIEQLD KISESPSEIM
ESLTAMYNIP KDKQTLLFTH IRLAHGFSNH KKRLQAVQAR LHAISILVYS NALQESANSI
LYNGLIEELV DVLQITDKQL VDIKAASLRT LTSIVHLERT PKLSNIIDCT GTASYHGFLP
VLVRNCIQAM IDPLMEPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG
DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFICRL EHEVDLSRKE CPFVIKPKIQ
RPSAAVESED MDTDMEMSEV AMESSPGPST SSGSRPEADH RAQSSAANTP RAGMQCIPQR
AALLKSMLNF LKKAIQDPAF SDGIRHVMDG SLPTSLKHII SNAEYYGPSL FLLATEVVTV
FVFQEPSLLS SLQDNGLTDV MLHALLIKDV PATREVLGSL PNVFSALCLN ARGLHSFVQC
QPFERLFKVL LSPDYLPAMR RRRSSDPLGD TASNLGSAVD ELMRHQPTLK TDATTAIIKL
LEEICNLGRA PEYICQKPSI QKADGTVAVP PARSSHAAEE ASSEDEEEEE ALHTFSQQQG
EPESNRQSVP LELVVGTEER IPIPLMDYIL NVMKFVESIL SNNTTDDHCQ EFVNQKGLLP
LVSILGLPNL PIDFPTSAAC QAVAGVCKSI LTLSHEPKVL QEGLCQLDSI LTSLEPLHRP
IEVPGGSVLL RELANAGHVT DATLSARATP LLHALTAAHA YILMFVHTCR VGQSEIRAIS
VNQWGSQLGL SVLNKLSQLY CSLVWESTVL LSLCTPNSLP PGCEFGQADM QKLVPKEEKP
SGSTAATTAS GSRRTAESET VSVDSSAGGL LEGMGLDGDT LAPMETDEPT ATDPKAKSKL
TPAMATRIKQ IKPLLSASSR LGRALAELFG LLVKLCVGSP VRQRRSHHAT STGTTPTPAA
RATASALTKL LTKGLSWQPP PYTPTPRFRL TFFICSVGFT SPMLFDERKY PYHLMLQKFF
CSGGHDALFE TFNWALSMGG KVPVSEGLEH TDLPDGTGEF LDAWLMLVEK MVNPSTVLDS
PHSLPAKMPG VTPTMPQFSA LRFLIVTQKA AFNCIRSLWN RKPLKVYGGR MAESMLAILC
HILRGEPVIQ ERLAKEREGT VRPDDEGVST GSLGPSGAPG ATTTGGEAPA PTGTTSGVPA
GGSADDSTNS TPRREPQVNQ AQLTQLMDMG FSREHAMEAL LNTSTMEQAT EYLLTHPPPL
LGGAVRDLTM SEEDQMMRAI AMSLGQEVSM EQRSDSPEEA ARRREEDDRR ARERAEEEEA
RCLERFMEAE PLDPQELHTF TDSMLPGCFH LLDELPDTVY RLCDLLMTAI KRSGPEYREL
ILGQVVHQVW EAADVLIKAA EPLTTSDTKT VSEWTRQMAT LPQASKLATR ILLLTLLFEE
LKLLGARVVE NSGILDLLIK LLEVVQPCLQ AAKEQKDIQT PKWITPVLLI IDFYEKMAVS
SKRREQMNKY LQPNGNNWRW FDDRSGRWCS YSASNNSTID SAWRAGESSV RFTAGRRRYT
VQFNTMVQVN EETCNRRPVM LTVQRVPRMP KPAKTGSITD SEREEADRSK VEETQTDLDS
GAAVEMSAPK DDSSQPKETT TTLEIDYSQR SDIVVQGLTE DMTTVLIRAC VSMISVPVDP
DTLHATLRLC LRLTRNHHYA MMFAELKSTR MILGLTQSSG FNGFTPLVTL LFRHIIEDPA
TLRHTMEKVV RSAVTSGAGS TTSGVVSGSL GSREINYILR VLGPAACRNP ECFAETASNC
VRIALPAPRG AGTASDDEFE NLRIKGPNAV QLVKTTPLKL SPLPPIPDTI KEVIYDMLNA
LAAYHAPEEP ERPEERAAAV PGGQDLCQIL QDVGDDVYQQ YRLTRQGSDF DSQSAFHINT
QVFAADGGVA ESSQSGTPQG EASTPEEMRE EKKEQEGEKG TSSDEGKAAK VKASKPLMPT
STILRLLAEL VRSYVGIATL IASYCYTAGQ SELIKEDCSV LAFVLDHLLP HTQNSEDKDT
PALARLFLAS LAAAGTGTDA QVALVNEVKA ALSRALAMAE GAEKHARLQA VMCIISTIME
SCPSTSSFYS TAAAKTQHNG MNNIIRLFLK KGLVNDLARV PHSLDLSSPN MANTVNAALK
PLETLSRIVN QPSSLFGGKG GSSKNKAEHD TVGTARDSNS NTQEQGESGE AEPVEGNHRV
QGTDSDLMDG ETEGDTVVIA GQPEVLSTQA MQVENELVDL IDELLERDAG TVNSAIIVGR
SGEDESQEDV LMDEAPSNIS QASTLQANRE DSMNILEPED EEHTQEEDSS GSNDDEDSQD
EEEEEEEEEE EDQVWINVMK LS
//
