GenomeNet

Database: UniProt
Entry: A0A3B4X2D9_SERLL
LinkDB: A0A3B4X2D9_SERLL
Original site: A0A3B4X2D9_SERLL 
ID   A0A3B4X2D9_SERLL        Unreviewed;       753 AA.
AC   A0A3B4X2D9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN   Name=SLC26A3 {ECO:0000313|Ensembl:ENSSLDP00000010381.1};
OS   Seriola lalandi dorsalis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000010381.1, ECO:0000313|Proteomes:UP000261360};
RN   [1] {ECO:0000313|Ensembl:ENSSLDP00000010381.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC       bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC       role in the chloride and bicarbonate homeostasis during sperm
CC       epididymal maturation and capacitation.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B4X2D9; -.
DR   STRING; 1841481.ENSSLDP00000010381; -.
DR   Ensembl; ENSSLDT00000010757.1; ENSSLDP00000010381.1; ENSSLDG00000008256.1.
DR   GeneTree; ENSGT01070000253775; -.
DR   OrthoDB; 1067648at2759; -.
DR   Proteomes; UP000261360; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU362052};
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        73..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        103..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        166..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        200..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        241..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        277..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        366..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        461..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          516..709
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   REGION          734..753
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   753 AA;  83647 MW;  A94E06D134047A81 CRC64;
     MMRPGAKQYV VARPLYSEET FAEKHEKVYR QRKTMLNHIK QYFTCDAKRA KNAALSLLPV
     IGWMKIYRVK EWLLSDIVSG LSTGLVAVLQ GLAYCLLASL PPWYGLFSAF FPVIMYFFLG
     TSRHISVGPF PVLCLMIGSV VTRLVPDEGP PVNITGFEGL TRDEQRVLVA SSVTFLAGIM
     QLAMGVFQVG FVVMYLSDTL VSGFTTAAAI HILVSQLKFV LGLQVPGISG PLSIIYTLEI
     IINKITSTNV CDVVISLVIM VVVFIVKELN DRFKSKLPVP IPIEVIMTVI ACGVSYAFDF
     KTKYGIDVVG HIPKGYEPPM APNLHIFQDT AVEAFPMAIV GFAVAFSVAK VYSVKHDYTI
     DGNQELIAFG VSNIFGASFK SFAASTALSR SAVQESTGGK TQIAGLLSAI IVMIVTLAIG
     FLLEPLPKSV LGAVVIVNLK GMLMQFRDVP YLWRRDKPDC IVWLGTCIAA ILLGLDLGLA
     AGLGVELLSV VLRAQFPRCS VLANIKGTDI YKDRKDYIDI YEQEGVKIFR IPSPIFFANI
     DFFRSKLVEA VGFNPLRVLR KRNKALRMIR KLLKKGDLQW TCNGLLNTSC RPIKESEDES
     NMEELDLPTD FKDLPTRIDW NADLPGNISV PRVEVHSLIL DFAAVSFLDI SALKGLKTSL
     KELIRVEVEV YIVACDPYIL EKLHHCCFFD DEVQPSMFFL TLHDAMLHIL EKHPESTEKK
     SNCEKIITTV TVHHPGGSLR STDRNVPDRE TRF
//
DBGET integrated database retrieval system