ID A0A3B4X2H9_SERLL Unreviewed; 609 AA.
AC A0A3B4X2H9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
GN Name=GLS2 {ECO:0000313|Ensembl:ENSSLDP00000011739.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000011739.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000011739.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR AlphaFoldDB; A0A3B4X2H9; -.
DR STRING; 1841481.ENSSLDP00000011739; -.
DR Ensembl; ENSSLDT00000012167.1; ENSSLDP00000011739.1; ENSSLDG00000009348.1.
DR GeneTree; ENSGT00390000010463; -.
DR OrthoDB; 537490at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR HAMAP; MF_00313; Glutaminase; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR NCBIfam; TIGR03814; Gln_ase; 1.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF33; GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 80..162
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
FT REGION 585..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 67949 MW; B7E875512FC862B0 CRC64;
MHCLKSLRTA NPGILQLFKN AGISARVGAD SIVLSRTQQP VPLPCWVVAS PHNHRAFHHQ
KGPDVDQGHS NTSRLMSSME DLLFYTITEG KEMIPLSQFI SALRKTGLLT SDPRLRDCVH
QMRQSTRDSV GPVMMDKKLF RRCVGNNIML LTKAFRKKFI IPNFAEFTQQ LNKMYDHAQQ
QEAGQVANYI PQLAKFSCDL WGVSLCTIDG QRYSVGDTKV PFCLQSCVKP LEYAIAVHEL
GSERVHNFVG KEPSGFKFNK LSLNEEDKPH NPMVNAGAIV ISSLIKPHSN KAERFDYVME
FLKSMAGTEF VGFSNATFQS ERETGDRNYA IGYYLKEKRC FPDNADMIAA LDFYFQLCSI
EVTCESGSVM AATLANGGIC PITGERVLSA EAVRNTLSLM HSCGMYDFSG QFAFHVGLPA
KSGVSGAVLL VVPNVMGMMC WSPPLDRLGN SVRGIHFCQE LVSCFNFHNY DNLRHFTKKH
DPRRRSDDDP NKSVVNLMFA AYSGDVSALR RFALSAVNME QRDYDSRTAL HIAAAEGHVE
AVIFLTEICK VNPHMKDRWG NTPLDDAMQF GHDVVISVLQ DYQRATTEGD SPGDPEEQKA
TLDTLKSIV
//
