ID A0A3B4X3U6_SERLL Unreviewed; 4050 AA.
AC A0A3B4X3U6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
GN Name=PRKDC {ECO:0000313|Ensembl:ENSSLDP00000010841.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000010841.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000010841.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR STRING; 1841481.ENSSLDP00000010841; -.
DR Ensembl; ENSSLDT00000011237.1; ENSSLDP00000010841.1; ENSSLDG00000008617.1.
DR GeneTree; ENSGT00940000155633; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0071707; P:immunoglobulin heavy chain V-D-J recombination; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0033153; P:T cell receptor V(D)J recombination; IEA:Ensembl.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2870..3523
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3707..4037
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 2048..2076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2712..2764
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4050 AA; 461030 MW; 5A7C970BB5DA496E CRC64;
MSSHGGAAGG IHGLLLKLHE SLSDEDSRAA ALRCHDIVGD LGQECMLTST ENDLALQMSL
LFSKDYGLLS FLRKSLPSEE FRDSRVEILL FLGTFLDRVS PRVKGWENTY ANDIKDTCMA
VYTKEKLAKC RTSVLELLIK VLQTTKASSV AADFKICEIF NKYYSELCQK SKLPDSVLGK
IYELLGVLAE VHPSEMSNNS DKLYKAYLGE LKEQMTSSTK EPKLFVVAGC LRGITSLMVN
FTKTMEEDPA TCKEIFQYAL KAVSPQMEMS RYAVTFAGLR LFARHASQFS SCLMDQYKTL
FEVMSKLCGH INAEMKKTSY YALESFLKQV AILVAENIEE HKTKLKFFMQ KFCGIIKTMD
STHKELSIAI RGYGFFAAPC KKVCPQDVDL MYTELIQRCK QMYLTESDGE EDSFYQLPSF
LDSIANVLIH LDKIPEVYTP LLERLLVVQI DSFPQYSERM QSSCCKSILK VLVATASKGP
VLWSFISSVV HQGLIRVCSK PIVLSENKDN GNDPSQSSQV RTGKWKIPAS HNYLGLFKGL
LDCDQLKDSG FLDGAFESQN AALVSLSRLL YDELVKSILR IVEKLDLSVQ KVTTGEEAPD
DAAHVLPSSD PTAHLLPNKI KDFTAFINLV DFCSELLLTR HVEYFQSWMY PLSHELILHS
IRNPLVSGFY KLLSVATKIA KRIKYYQGVG RRSSTSPQSD SVKSACFALF SKFGKEVCVR
MKQYKDELLS SCLTFVLSLH HSIVALDIKA YCPALEAALK LGLSHAPLAN AALDALEDWS
SHIPLETMQP CYTNILPLLD GYLKTTSNNN KDDSSWEVMS SSSSRRDKGY SKVMTRLLKQ
SKQLSTEDAP LVTVRLRVVK LLGHLGGKLN RNLVTVVSSE EKMKKFVAWD SEKRLNFAVP
FTDMKPVIYL DPFLPRISEL ALSTSDRQTK VAACELLHSL VVYMVGKSAQ MVEGKNTLPP
MYKLHKRLFP VLLRLACDVD QVTRQLFEPL VMQLIHWFTN NKKFESQDTV AVLEAILDGV
VDPIDSTLRD FCGRCIEEFV KWSIKQTTPK QQEKSPTNMK SLFKRIYSLA LHPNGFKRLG
AALAFNSIYR QFREENSLVE QFVFEVLVIF VESLALAHSD ERSMGTLQQC RSSIDHLKRI
IKHKAPSLNQ HNAKRRVPRG FPPDEKLCLS DMVLWLLEQC GRPQTECRHK CMELFYEFVP
LLPAKNSPPQ WLDGMLKDHG ISFLISRFEG GGLLSQPTLR DLTGPFSVRA TLQWMDLLLA
ALDCYNTFIS LHIIKPQHML SSKDESSFLK AVRFFLTELA TQELAAAESC FHLGAKNSHF
SPREVDQYNY SKCTIIVRLL EFATMILVKG DEEFWKLLEH DIFCAVFFEL TALAVCEPST
VGFNMADVEV MKNLPEVCVP LLKALLSSTY RSHLESSLRT KISRKSVEEL CAVDFYHSGT
LSQHDQMEMV LFSCKQIHKA GFLSSILHSQ DSAYAKSLGY QLLMTVYKGI APGEDRNALP
SLDVNTRRVA DGLLQLAFSL SQQSEKLVDL LLNTIMLSVP ISGSQSHNFL SFSHGEYFYS
LFQTTVNTEL LRSLDTTVPH LMNASSQNPS MVSTLLNGLL DHSFRERSVR KTQGKQLVEE
VLRRWNSLQS WWEGQSSTPE SKTATLLLLS KLLQIDSSVC SNVNHEAFRK VFSTFTLLLV
DMTLPLNLKS QALLVLPFFT TLPEEPLAEL QRALDALVVS HFPMQSDEFA KGSLHRNNYM
DCIRKLLDAL ELSQSPLLLK LLSGILCRDR KHIMEEQFQT CFQRIAKRSS SERQLQLLCT
VYGVIQKGDV PVSSMLQAMM ERVLLPLASY CSTTALSDFF VANVSDIIEL LLSRFTKSSE
TAFELQLLKK NGCYKLMELL YSQLPKEEVY SKESRINQAY CRSNKTEGNE LSKALIKSCF
EAFTENMAGE TQLLELRRHF HCAAYNCAIA AISCSFSEPK FYHGFLFSEK PEKNQFILEN
IIDVERTYNF PVEIEVPLER KKKYIMIRKE VNEENGEAPV YLSSQSYMAD SSLSEEMSQF
DFSTGVQSFS FSSQNPEGQR RTVAKRETEE TNPSQDAMVD LEMDELNQHE CMATLTALIG
HMQRSNITPK IEQGNEPSEL PPWMKFLHGK LSNPATPLNI RLFISKLIIN TEEVFRPYAK
HWLGPLLQLV VCGKNGGEGI HFMVVDVVVT VLSWTSLANP KGNPRDEVLA NRLLEFLMKH
SFHSKRAVFR HNLEIIRTLV ECWKDCLHVP YSLIYERFCG TDPNSKDNSV GLQLLGIILA
NNLPAYNASC EIEYERYIQS LTNNMSFVRY KEVYSAAAEI IGLILKNMNK TDNQHQELVS
LAASKIANLK KTHMDDKFII CLNKVSKHFP PFMDRFVNYV FSILPKLHGI LKTHCLECVL
SRADVIPDIF MQLKTTGFIQ MMGHRDEARQ RMCLDIVHKI IGLLTPVELQ ELLGAVTAFV
SHPSPVCRER MYDILMWIQD NYSDAESMDD STSVEVLNAA KETLLQGLSE ENQGLQLYVQ
NFWSQEKRLP TTTLDRMLMV LGSLYSCQIE RCFLSLVTNL LLEMTSRSPD FERNMFEYPL
SECTFQDYVI DSNWRFRSTV MTPMFVETQS SQGPESVAAS QAGAMKGKLR ATQTSLEFTQ
TQTTGRRTAY NWLTGSSVDT LAEHTLGSES LSSLLVFDKK AERQTAARRP VGEGFGLRRL
TAPSDEVDSR TRAETEQRNN ILRLRRRFLK DQEKVGLRFA QKEIQQQRKK KEEKADQRLR
KEAQVTLYRN YRVGDFPDIQ IPYSSLIAPL QALAQKDPIL AKQLFSSLFA GILQEMEKDK
PGESGRIKEK LRGNMNAFLS KSTLCFPPFI ACVQDMCYQH KDLQQLDPVA ISSTCQVSLQ
QPSGILLLEE SLLHASVQGE PPAKRSRERK EIPPDTKKWI HLARLYRSLE DYDVVRGIFG
GKVGTKSVTC AALQAEANTD FAEAVKLYNE ALNTEDWRDG EPTDSEKDFW EIAAMEAYSH
LTEWKSLQYC STVYVDENSP PDLEKMWSEP LYQEMYLQHM IRSMLKQLQQ GERDQTLLSF
IDKAMRVEER KKLLESHYSQ ELSLLYILQE DYDRAKYYTN YAMQLFIESY SSVDTLLTQS
RLTILQSVQA LTEIQDFLLF IKGDVSVNGL KRLVRLWTER YPDAKVDPVK VWDDIITSRC
FFLDKIRDKL RGHAPSDSME VDGSDPEGDI ETLVNECKFN MKLHMADSAR KQNNFAVATK
LLKDLHREAK TNRGWLRQWV HSFTRYSHKR SQALGPGEQI SSMLKIIPLL EDLQADCERA
TAKVFRYQKV LQGTSFHILA TAVSKSPSVL GAIEREKAER VVRLSRVAWP TENPKEVEAG
LQLQALELLR DASRKADEEL QSYSQDFVES SSITETYMAL ANFCDKRLRE EEQSDAESQS
PDLLSLPVHV VESMLKALKM NSEDARLRFP RLLQLIDLYP SETLDIMTKE MMSVPCWMLI
SWISQMVALL DKPEAVAVQH CIGQIAECYP QALVYALMIS SETYQFEDSA TGHHQQEFVN
RLRSMLDKGG AVKKFVDALQ QLTNPDMIFK DWWDYVKNEL EKPNFDKKRM SNMYDEMHSS
LGDRNADGHG TFRKKFIQKF GKDVEKLLGA KGSKLFEKRK DKSFVRQVDE MAVSMRGFLT
EPGNLKEYSP WLSGFKADTF SNELEIPGQY DGRSKPLPEY HAKITGFDER VKVMSSIRRP
KRLIIRGDDE RDHPFLVKGG EDLRQDQRIE QLFAVMNILL SRDAACTHRG LQLRTYQVIP
ISTRIGLIEW MENTCTLKDF LNTTMTDKEK QSAQRPVEDY NKWLSTFAPN SKVNPISLYG
LAYKKAKRAD TVSNFLKVMQ HVPSDLLKRA FLKMCNSPEA FLSLRSHFTS SHALLCVSHW
ILGIGDRHLS NFMINMETGG MIGIDFGHAF GSATQFLPVP ELMPFRLTRQ FVTLMQPLKE
SGLIQSVMVH SLRAYRAEPD LLLNTMDVFV KEPSLDWKNF ELKQLKKGGT WTESVNTKEI
NWYPLQKVDF ARRKLEGANP AAITRYLTSR
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