ID A0A3B4X4K3_SERLL Unreviewed; 1628 AA.
AC A0A3B4X4K3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Pappalysin 1 {ECO:0000313|Ensembl:ENSSLDP00000010622.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000010622.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000010622.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M43B family.
CC {ECO:0000256|ARBA:ARBA00008721}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR STRING; 1841481.ENSSLDP00000010622; -.
DR Ensembl; ENSSLDT00000011010.1; ENSSLDP00000010622.1; ENSSLDG00000008407.1.
DR GeneTree; ENSGT00940000156654; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR CDD; cd00033; CCP; 4.
DR CDD; cd04275; ZnMc_pappalysin_like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR011936; Myxo_disulph_rpt.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR043543; PAPPA/PAPPA2.
DR InterPro; IPR008754; Peptidase_M43.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR NCBIfam; TIGR02232; myxo_disulf_rpt; 1.
DR PANTHER; PTHR46130; LAMGL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46130:SF2; PAPPALYSIN-1; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF05572; Peptidase_M43; 1.
DR Pfam; PF00084; Sushi; 3.
DR SMART; SM00032; CCP; 4.
DR SMART; SM00560; LamGL; 1.
DR SMART; SM00004; NL; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50923; SUSHI; 3.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1628
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017361748"
FT DOMAIN 1218..1289
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1290..1351
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1417..1473
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 65..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1628 AA; 181966 MW; 8D63674817F97B83 CRC64;
MKLWTSPWVS CLVILILCFG SECGTARRKG RSKRELVRIR EAKATIPGAC ATRLPRGKRS
LPGLERRVLR QHRRSSHAEE NSPDRGNAVY FTGMGDQLRL KPGVEIPRGN FTLEMWIKPE
GGQRSPTVIA GLYDKCFYAS SDRGWLLGIQ AVSEHGNREP RFFFSLKTDR AHKVTSIHSN
ARYVPNQWAH VAVTYDGVYM KQFVNGAQVG VSREQSGDVF SHLTKKCKVL MIGGNALNHN
YRGAVERVGL WRQARGQRQI IRDMQGHDDP QDLPQLVIRE TFEHPSRKWL TVKDGSFPLL
EQGGGGRFMG GGGVGNAEGL LDTTLDPPTC GQTVCDNVEV INNYNQLWTF RRPKKVRYRV
INIWDDARMR PTVSDHQISL QHQQLNDAFS PYNITWELSI HNVTNSSLRN RLILANCDIS
KVGDDACDPE CNHPLTGFDA GDCMSGHRSR CPEHKQGNGV CDPECNWENF LYDLGDCCNP
NVTDVTKTCF NRSSPHKAYL DVKELKEILH LDGSTHLNVF FANSSDEDLA GVATWPWDKE
ALTHLGGIVL NPSFYGTFGH TDTMVHEIGH SLGLYHVFRG ISEIESCNDA CLETEPSMET
GDLCADTNPT PKYKGCHDPE PGNETCGCRH FTHTPFNNYM SYADDACTDS FTLNQVARMH
CYLDLIYQTW QPYSKPPPVP MAPQVVEQHH NSITLEWFPP ISGHFYDREV GSVCDKCTEG
KVLLQYASNS SSPRPCAPSG HWSPREAEGP PDVEQACEPS VRTWSPNAGT EHGVVGLSEC
PLQGCMLQLE FPYPLVPDSL TVWVTFFSPE EAALPAIHNI LLLTVSGNNI PLGPSHVFCD
TPLTLKLDTE EEVYGVQFFT MEQHLEIDAT LLASKPDCIL CRHCQPLRYR LLRQPPFTHA
PHSLMLNEPT RRYTDRDVVP HVAYTYQVQT ISSRSESEPS PPLVHELGSP YCGDGQIQSS
KGEECDDMNS MNGDGCSSQC KKEPFFNCVE EPSMCYYYDG DGVCEDFERE TGVRDCGLYT
PSGFLDQWAS TVEVSHEEKP YCSGEVAAGY PAVTKTCQSK VFDLSDGVSQ YAWFPCREAH
ESAWGYPSYW LKAHFSHPMV AAAVIIHLAA DGTGYIDQTQ CNITVQLVDT KEGIHSLGEW
RLSCRTNPLV IPVNHDLSVA FYHTKAILVM FASRLVAISG VGLRSFQSFD PITISGCQSN
EIYNPTGQSC VHYSCEAIDC QEPLIRNAEL KCSSPGRHFY NGDRCTISCN SGYVLQIHQD
DDIIKSQSDS SVTITCANGK WNKQVSCEPV DCGLPDKYHV HPAHFNFPDG TTYGKKITFQ
CREPAQLVGT NNTLTCLEDG LWSFPEALCE LRCPAPPPVP NAVLQTKRCN ETGLKVGTLC
KYKCKPGYHV TNKPKRRAFK RQCTEDGSWL EGACEPVTCD PPPPIFHGSY HCTDGFRFDS
VCRLNCSDPG AASNVIRCRK DGNWTGSFRL CPHSKGQCSL PQNLHYSLQY SCKRGHGIGE
ECELSCRESN NDVVILPSNM TVESVLKEHW RNPNKVKTMV CTMGLKWYPH PEFLHCIKGC
EPFMGDNYCD SVNNRAFCNY DGGDCCQSTV KTKKVIPFPM SCDIRDECSC RDPNAIENRK
DEHVHSLG
//
