ID A0A3B4X5Y9_SERLL Unreviewed; 857 AA.
AC A0A3B4X5Y9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Receptor-type tyrosine-protein phosphatase-like N {ECO:0000313|Ensembl:ENSSLDP00000011556.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000011556.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000011556.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 8 subfamily. {ECO:0000256|ARBA:ARBA00025723}.
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DR AlphaFoldDB; A0A3B4X5Y9; -.
DR STRING; 1841481.ENSSLDP00000011556; -.
DR Ensembl; ENSSLDT00000011969.1; ENSSLDP00000011556.1; ENSSLDG00000009077.1.
DR GeneTree; ENSGT00940000154095; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR029403; RESP18_dom.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE-LIKE N; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF14948; RESP18; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 587..847
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 766..838
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 65..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..306
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 94614 MW; 89A2BF57E13FEA4F CRC64;
TRDQFCSDDG LFGQCLSSKQ DQVQYQVSVP VLKRMQEVLK QLMLQGLSWQ DDITQYILSK
ELKRVPHTTH PPKPNFSSSS SHPPHSKSGS TPSAGNYVDY MIVEPPQSQL RMQTASMDPY
TYHQHRYQDE VERSLLGAGG SYARPSSRSQ ANQRERERDR QLLQEALSLY LASAQPSYRH
RGAASMAPAG LPYYDDLELD IPIDYVEGYN LEERLGTAGR QQMLQNKKVP QDYSTLSGNN
DGLLQRMSGV LQRYGVDPRE LSQEQLYKLA LILQLLQMQL LKTDSVSNKP QKPVPVPGPP
DAPLAPSSAS IPATPAAKSS SPPPSATQPP QAAPAEAGQG LKEQGPPLVE GMGAKEEYGY
IVTNQSPLGL YDGVKLLELL ADKIHLTTSS FINISVVGPA LTFRIRQNEH NMTAAEVAAK
AVSEKNFLES QTGLKIVQTG VGERTDARGL PQVTRVSQGS SGTVITLVSM AVVGGVLVLA
MAVACLRHYA QQVANGKLGL GPEGGAETHF DYQDCVATGA GGRRGTDTSR VSSVSSQFSD
GPQHSPSSTH SSTPSWSEEP AQSNMDISTG HMILAYMEDH LRNKDRLQKE WEALCSYQAE
PSSVAAAQVP SNMDKNRNAE SLPYDHTRVK LKTDLNPNKQ DYINASIICD HDPRQPAYIA
TQGPMSHTVA DFWQMVWENG CTVIVMMSAL VEDGEKQCER YWPDEGSSLY HIYEVNLVSE
HIWCKDFLVR SFYLKNVQTQ ETRTLTQFHL LSWPADGIPT STRPLLDFRR KVNKCYRGRS
CPIIVHCSDG TSRTGTYILI DMVLNRMAKG VKEIDIAAAL EHIRDQRPGL VRTKDQFEFA
LTAVAEEVNA ILKALPQ
//
