ID   A0A3B4X9N9_SERLL        Unreviewed;       707 AA.
AC   A0A3B4X9N9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE            EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
OS   Seriola lalandi dorsalis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000012806.1, ECO:0000313|Proteomes:UP000261360};
RN   [1] {ECO:0000313|Ensembl:ENSSLDP00000012806.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMTC family.
CC       {ECO:0000256|ARBA:ARBA00007882}.
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DR   AlphaFoldDB; A0A3B4X9N9; -.
DR   Ensembl; ENSSLDT00000013274.1; ENSSLDP00000012806.1; ENSSLDG00000010130.1.
DR   GeneTree; ENSGT00940000158521; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000261360; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR013618; TMTC_DUF1736.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44227; -; 1.
DR   PANTHER; PTHR44227:SF3; PROTEIN O-MANNOSYL-TRANSFERASE TMTC4; 1.
DR   Pfam; PF08409; TMTC_DUF1736; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   Pfam; PF14559; TPR_19; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 3.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        112..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        225..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        354..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        441..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          293..365
FT                   /note="DUF1736"
FT                   /evidence="ECO:0000259|Pfam:PF08409"
FT   REPEAT          482..515
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          516..549
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          584..617
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   707 AA;  79499 MW;  B97A271DFB04CCD8 CRC64;
     MALSEVYWDR EIPLPKLAPV QAKVTVALVA LLCFINSYDG EFVFDDSEAI VNNKDLKPAT
     PLNNIWTNDF WGSNLSSNSS HKSYRPLTVL TFRLNYLVAG GLHPVGFHVL NIALHAVISA
     LMIDVFAILI GGLAYDENNR KLNHAPKTSL LAALFFAAHP VHTESVAGIV GRADLLCALF
     FHLSFLTYCK AFNRGSDRDD RFSVQWVVVS LLLCAAAMLC KEQGITVLGV NAAFDVLLIC
     NVNVYELSQR LLLRKNPLDV SEMLRTGLLT RLALMGLGGL SMLYARWRIM GTGPPAFTEV
     DNPASFAENI FLRIVNYNYY YSLNAWLLLC PWWLCFDWSM GCVPLIKSAT DWRMVWLLLL
     WCVLIGLISQ ALCSQDSQRR RTLTLGLVLL VVPFLPACNI FFRVGFVIAE RVLYLSSAGY
     CLLLAYSLGH CCYHWNKYRK LLCVSVLLLL CVYVARCALR SHQWRSEQSL FTSALPVCPL
     NAKVHYNVGK NLADRGNTTA AIRYYREAVR LHPTYVHAMN NLGNILKERN ELIEAEQLLS
     KAVSIQPDFA AAWMNLGIVQ NSLQKFGEAE QSYWNAIRFR KKYPDCYYNL GRLYADQNRH
     VDALNAWRNA TVLKPDHSLA WNNMVILLDN TGNLGQAELI GREALKLLPN DHTIMFSLAN
     VLGKLQKYKE SEGFFLHALR INPNAASCHG NLGKATATLL ITHILHS
//