ID A0A3B4XBM4_SERLL Unreviewed; 2436 AA.
AC A0A3B4XBM4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Teneurin transmembrane protein 2 {ECO:0000313|Ensembl:ENSSLDP00000015149.1};
GN Name=TENM2 {ECO:0000313|Ensembl:ENSSLDP00000015149.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000015149.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000015149.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 1841481.ENSSLDP00000015149; -.
DR Ensembl; ENSSLDT00000015724.1; ENSSLDP00000015149.1; ENSSLDG00000011996.1.
DR GeneTree; ENSGT01030000234566; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF8; TENEURIN-2; 1.
DR Pfam; PF05593; RHS_repeat; 1.
DR Pfam; PF06484; Ten_N; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 2.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 120..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..120
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 413..445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 480..515
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2395..2436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2413..2436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 435..444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 484..494
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 505..514
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2436 AA; 269387 MW; 35DFF294FAF8D748 CRC64;
PHNHHTLSHQ SANSLNRNTL RGGRNPIHAP APGTGDGPTT PESVQLQDSW VLNSNVPLET
RHFLFKTSSG TTPLFSSSSP GYPLTSGTVY SPPPRLLPRN TFSRSAFKLK KPSKYCSWKC
AAVTAIAAAA LLAILLSYFI AINLLGLTWQ LKPSDGPVLN NGLGAGLPVN SDVATLPSGG
RGPWAGRNSS IDTGNIEVGR RATQEVPPGV FWRSLLHLSQ PQFLKFNISL GKDALFGVYI
RKGLPPSHAQ YDYMERLDGK EKWSVVESPR ERRSIQTVVL NEAVFVQYLD AGAWHLAFYN
DGRERETVSF STNIMDSVQE CPRNCHGNGE CNSGVCHCFP GFHGMDCSKA ACPVLCSGNG
QYDKGSCVCY SGWKGPECDV PITQCIDPLC SGHGTCTDGN CVCSIGYKGQ NCAEVDCLDP
TCSNNGICVN GECHCKPGWG GLHCELPRAQ CPDQCHGHGA FIPDTGLCSC DPNWMGPDCS
MDGCPNLCNG NGQCTMGQQS WHCECQTGWR GPGCSVAMET SCADNKDNEG DGLTDCMDPD
CCIQSPCQNS PLCRGSRDPL QVIQQSPMSQ PHVRSFYDRV KMLVGRDSTH IIPGENPFNS
SLASLIRGQV LTTDGTPLVG VNVSFVNYPH YGYTLTRQDG MFDLIANGGA SLTLRFERAP
FLSQERTVWL PWSQFYAMDT LVLKTEENTI PGCDLSGFIR PDPLVIASPL SSFFSSKPGE
KPIIPETQVL HEQIEVPGTS LKLCYLSSRT QGYRSLLKVT MTPAVVSMGL LKVHLMVAVE
GHLFQKWFHA SPNLAYTYIW DKTDAYGQRV YGLSEAVVSV GYEYESCASL ILWEKRTAIL
QGYELDPTNL GGWSLNKHHI LNTRSGILHK GSGENIFVTE QPPVITSIMG NGRRRSISCP
SCNGLADGNK LLAPVALAMG IDGSLYVGDL NFVRRVYPSM NTTGILELRN KDFRHSNNPT
HKYFLAVDPV SGALFISDTN SRRIYRVRSL TGGRLLSDNA EVVAGTGEQC LPFDERCGDG
GKATEATLMS PKGIAVDKNG LMYFVDATMI RKVDQNGIIS TLLGANDLTA IRPLSCDTSM
DVSQVRLEWP TDLAVNPMDN SLYVLENNVI LRITENHQVS IIAGRPMHCQ VPGIDYSLSK
LAIHAALESA TAIALSHTGI LYIAETDEKK INRVRQVSTN GEISLLAGAA SDCDCKNDVN
CNCFYGDDGY APDAGLNSPT SLAVSPDGTL FIADLNNIRI RAVRANRPGP AVSSVGYGGS
AQYEVASPRE QELYVFNGEG LHIQTISLVT GEPLYNFTYG PDGELSMLVD NCNNTVKVRR
DGLGQGGGAG LLRLVLLPEN QVVTLGLDPT GGLRSVSALG QEVALMGYSG NTGLLATKAD
ETGWTTFYQY DSEGRLTNVT YPTGMVTSLH REIERSINID IESSSRDDDV TVITNLSSVE
ASYTVVQDQV RNSYQLCNNG TLRVMYANGM GISFHTEPHI LAGSVSPTIG RRNITLPTDN
GLNSIEWRLR KEQTKGKVTV FGRKLRAHGR NLLSIDFDRN TRTEKIYDDH RKFTLRIMYD
AQGRPAMWLP SSSLAVVNVS YSTTGQLVGL QRGSMSERTE FDPQGRILSR SFVDGKVWSY
SYLDKSMVLL LQSQRQYVFE FDASGRVTAV TMPSVARHTM FTHVSVGYIR NTYNPPESNA
SIIHDFCEDG RPQATHYLGT GRRVLYKYGK LAKLSEIVYD STAVTFGYDE TAGVLKMVNL
QSGGFSCTIR YRKMGPLIDK QIYRFSEEGM VNARFDYTYH DNSFRIASMK PVISETPLPV
DLYRYDEISG KVEHFGKFGV IYYDINQIIT TAVMTLSKHF DTHGRIKEVQ YEIFRSLMYW
MTVQYDSMGR VVKRELKIGP YANTTQYRYD YDGDGQLSGV KVNDWSTWRY SYDLNGNLHL
LNPGNSARIL PLRYDLRDRI TRLGDVQYRV DEDGFLSQRG SDVFDYNSKG QLLRAYNRGP
GGWSVVYHYD GLGRRVSTRN SLGQHLQFFY ADLNHPTRVT HIFNHSSSDI SSLYYDLQGH
LFAMEVSSGE EYYIASDNTG TPLAVFSSNG QMIKQVQYTA YGEVYLDSNP EFQLVVGFHG
GLYDPLTKLV HFTQRDYDVL AGRWTSPDYS IWPKIGKDPS PFNLYMFKNN NPLSDMLDVK
NYVTDVKSWL VMFGFQLSNI IPGFPRHSLY FVEPPYELQA TQHCENGQLI TGVQQAAERH
NQAFMALEGR LLNKERRRRK DKPGHWFGTS TPIIGRGVML ALKEGRVVAG VSALASDDSR
KVALVLNGAQ YLEGTHYTQD GKDCHYFVKV GSADSDLLTL GLTNGRKSLE SGINVTVSGR
SRRGVTVEFA VPSLVLSVRY GLAVDVVDEE KVRLLELARQ RALAGAWAKE QQRTLKAKGP
KWRQSHSREQ PLQLHINRGH HKTVTDKARL KDRPIL
//
