ID A0A3B4XH78_SERLL Unreviewed; 569 AA.
AC A0A3B4XH78;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
DE EC=2.3.2.27 {ECO:0000256|PIRNR:PIRNR015614};
GN Name=TRAF2 {ECO:0000313|Ensembl:ENSSLDP00000015522.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000015522.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000015522.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|PIRNR:PIRNR015614};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR AlphaFoldDB; A0A3B4XH78; -.
DR STRING; 1841481.ENSSLDP00000015522; -.
DR Ensembl; ENSSLDT00000016100.1; ENSSLDP00000015522.1; ENSSLDG00000012317.1.
DR GeneTree; ENSGT00940000156621; -.
DR OrthoDB; 2913784at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:InterPro.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:InterPro.
DR CDD; cd16639; RING-HC_TRAF2; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR027133; TRAF2_RING-HC.
DR InterPro; IPR049441; TRAF2_Znf.
DR InterPro; IPR049440; TRAF3/5_RING.
DR InterPro; IPR032070; TRAF_BIRC3-bd.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF159; TNF RECEPTOR-ASSOCIATED FACTOR; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF21341; TRAF2_zf; 1.
DR Pfam; PF21363; TRAF3_RING; 1.
DR Pfam; PF16673; TRAF_BIRC3_bd; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR PIRSF; PIRSF015614; TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 2.
DR SUPFAM; SSF57953; Trimerization domain of TRAF; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015614}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 34..72
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 125..170
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 177..233
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 419..564
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 125..170
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 177..233
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT COILED 326..395
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 569 AA; 64173 MW; 238DC9B050B197BB CRC64;
MAAQEPSPPS SLEGNKPGFP KKILANNLED KHLCNSCQKI LRRPLQAQCG HRFCSFCFNK
IVSSGPQKCS ACIKEDLFEE PTSILKQGGA FPDNAARREV EALAAVCPNE GCTWTGTIKE
FEAGHEGNCD FMIILCPSCK ELMRANEQER HNERECPERT LNCKYCKEPF LLKNIKAHDE
ICPKYPMICE GCAKKKIPRE KYVDHIKFCS KFKAPCRFHV VGCDTSVEKE KIHDHERQCS
YEHLNLLLHF IMGIKVSLES LQPQSLEVAS HKLQELHQSL RDLEQKMSQL GGGGGAAPVQ
GACAPTLATS FTPLPSAMGA ALELQLQSEK TKVAELSRRC QELELKVSTF ENIVCVLNRE
MERSCTTMEA YNRQHRLDQD KIEILNNKVR QLERTVSLRD LSIVEMEGKM REMSAATYDG
IFVWKISDFT KKRQDAVAGR APAMFSPAFY TSKYGYKMCL RIYLNGDGTG RGTHLSLFFV
VMRGHSDALL KWPFNQKVTL MLLDQNNREH IIDAFRPDIS SSSFQRPVSD MNIASGCPLF
CSLSKLDSKN SYIRDDTIFI KAIVDLTGL
//
