ID A0A3B4XKE0_SERLL Unreviewed; 1386 AA.
AC A0A3B4XKE0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Patched 2 {ECO:0000313|Ensembl:ENSSLDP00000016727.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000016727.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000016727.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR Ensembl; ENSSLDT00000017325.1; ENSSLDP00000016727.1; ENSSLDG00000013192.1.
DR GeneTree; ENSGT00940000159901; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF3; PROTEIN PATCHED HOMOLOG 2; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 314..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 926..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 953..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 982..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1021..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1052..1074
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 313..471
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1106
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1386 AA; 152446 MW; F45D8D5A993EDF1E CRC64;
MASDRGVPGA GVFGDLPPSY TRSQPPANPD LLRRPSYCHA AFALKQISKG KAVGQKAPLW
IRARFQALLF SLGCHIQRHC GKVLFIGLLV FGALSVGLRV AAIETDIEQL WVEAGSRVST
ELRYTREKQG EESVFTSQML IQTPKEEGTN ILTQEALLVH MEAALSASKV QVSLFGKSWD
LNKICYKSGL PIIENIMIER MIDKLFPCMI ITPLDCFWEG AKLQGGSAYL PAEALQTMFL
LMSPKQLYEH FKDDYEIHDI NWNEEKATAI LESWQRKFVE VVHQSIPANS SQSIHAFSTT
TLNDIMKSFS DVSVIRVAGG YLLMLAYACV TMLRWDCAKS QGAVGLAGVL LVALSVAAGL
GLCSLLGLSF NAATTQVLPF LALGIGVDDM FLLAHSFTEA GSNIPFKERT GDCLRRTGTS
VALTSINNMI AFFMAALVPI PALRAFSLQA AIVVVFNFAM VLLIFPAILS LDLHRREDKR
LDVLCCLYSP CSDRVIHLSP HELSDAGEQP HTPTTATAHT HQYAAGSTIT TSTQITTTVQ
AFTQCDAAGQ HIVTILPPTS QISTSPPSII LCPTSQAQAI TPSLTTTSVP DPYGSQLFTP
TSSSTRDLLA QVEDSRSGKK CVPLPFLHWN LSSFAREKYA PLLLKPKSKA IVVVLFLGLL
GLSLYGTTMV HDGLYLTDIV PRDTKEYDFI DAQFKYFSFY NMYLVTMDGF DYARSQRLLI
QLHNAFNSVR YVVRDSDNKL PRMWLHYFHD WLRGLQAAFD ADWQAGRITA DSYRNGTEDG
ALAYKLLIQT GSKKEPFNYS QLTSRRLVDA DGLIPPEVFY IYLTVWVSND PLGYAASQAN
FYPHPREWIH DKYDTTGENL RIPAAEPLEF AQFPFYLNGL RQASDFVEAI ESVRAICDEF
SRKGVFNYPN GYPFLFWEQY IGLRHWFLLS ISVVLACTFL VCAILLLNPW TAGIIVFILA
MMTVELFGIM GLIGIKLSAI PVVILIASVG IGVEFTVHIA LGFLTAIGNR NKRSAVALEH
MFAPVVDGAI STLLGVLMLA GSEFDFIMRY FFAVLAILTV LGMLNGLVLL PVLLSMMGPP
AEVTPVDNAS RLPTPSPEPP LPPPMTHHGY YTGHHNPRSS HQQAFSESSD SEYYSEMTTT
SGIGEEDYKY CDRSAYITSH TSVPPATSHI LLEASKNPSF PKLTVVKPFK ENTTGTGGRI
EPINESSHNA QSPLSSQVTC WDGNKREQQQ GLHRLQAQPG QHLPSDRAHF PGRTCQSGPR
LQNGRGPQPN RTKGASYSNS TSALPPQQGS TGGPVTMVTA TASVTVAVHP TLPGAAYQGY
MHEGFDTDSE SDCFEAAKRT CGDKTNFSSC KRDSLEIQDL EATQCQTEHQ FGKTQGGLRI
QAAKDC
//
