ID A0A3B4XKW7_SERLL Unreviewed; 1041 AA.
AC A0A3B4XKW7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=NLR family CARD domain-containing protein 3-like {ECO:0000313|Ensembl:ENSSLDP00000016370.1};
GN Name=NLRC3 {ECO:0000313|Ensembl:ENSSLDP00000016370.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000016370.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000016370.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR AlphaFoldDB; A0A3B4XKW7; -.
DR Ensembl; ENSSLDT00000016967.1; ENSSLDP00000016370.1; ENSSLDG00000012959.1.
DR GeneTree; ENSGT00940000159861; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF285; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 7.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 10.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 38..130
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 215..346
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1041 AA; 114864 MW; 7B6724804977B054 CRC64;
MERKAHYDSI LDRSKRITWQ DDCYVDLQST SCSLSSQAET EELSWIKKHQ DELRRFTSAS
FLEEMLAHLR KVNVLSSAEE TKIKEAGRLQ DQVNMLTTTV SGKDTQGSDA LQGFVESSDS
QVAQLIINHD YMVKEHKEVL LRRYEQCRDR DSVSCPKLNI SARTLLLVDG LSDIQQKEHD
LMQVGATQGG KRNHLRQLVL AKLLEPLTRV SLPPRVSLTV GVAGIGKTTW VRHFIRQWSQ
GAICSDVSFV LPFTFCQLNS LEKLSAEKLV KMAFPHLTDP NLILSSSCRT LLILDGLDEF
RCTLNFSDAA PCSDPKKEVS IDDLVTNIIR GNLLPDVAVW VTSRPGVASL IPGGLVDRVT
EIPGFSPKDI QIFLNHHFSE KDFARKIWAH LESHKILMVM CYIPCICWIV ADTLMYIMQS
ETQESLPRTC TELYAHFCSM KAEVGEPRGR EPVKTEQLHG SNRKLLGNLG RLAFYGLLKH
KYTFSEQDLR AYGIDLLLTQ GSLGAGVLVR EESAIYTTYR FTHLTLQEFL AATFYHISSK
RAIFDLFSES TMSWPKIGFQ NHFRSAFQHA QQAEEGHLDV FVRFLTGLLC PMALKPLAGL
LALGKDDGNQ KGWAAGFLQG LLDSGGAVVS LRAVNLAYCL QELQHTELLR SVEDDLRLGS
LAGKLSRAHC VVLGYLLHVS PECSEQTNLT GSLNYATVKC LLPQLLYCSH LRLENNHFKD
DVMELLGSLL SAKDCHIQKI RIVINILHHM IVTTFIHPLS LAENAISNKG AKALSRALLV
NRTLISLKLQ SNSISNRGMT ALTKALRLNR GLVSLNLREN SIGVEGAKNM AHALHENNSL
QDLDLTANLL HDDGVQAIAG AIKFNQGLTS LHLQWNFIKS SATKALAHAL ISNSTMQLLD
LQENAIGNEG VIFLAEALKT NASLHTLCLQ GVSAGTKGAI AMAEALLTNQ TLQTLDLRGN
TVGMEGAKAL ANALKSNRSL KSLNLQENSL GMDGAIFIAT ALKGNHQLTY INLQGNGIGE
SGAKVISDAI RANAPGCVVD I
//
