ID A0A3B4XL54_SERLL Unreviewed; 1008 AA.
AC A0A3B4XL54;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
GN Name=FARP1 {ECO:0000313|Ensembl:ENSSLDP00000017061.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000017061.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000017061.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
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DR AlphaFoldDB; A0A3B4XL54; -.
DR Ensembl; ENSSLDT00000017666.1; ENSSLDP00000017061.1; ENSSLDG00000013411.1.
DR GeneTree; ENSGT00940000155318; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17189; FERM_F1_FARP1; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 41..321
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 504..695
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 724..821
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 897..994
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 115680 MW; 92B693D00A1D1BCB CRC64;
MVEPADRPST AGQRLGAPES FGVSTLEPGL RPPAQPPGRQ VSIRVQMLDD TQEVFQISQR
SPGKVLFDLV CVHLNLTEGD YFGLEYQDHR KMTVWLDLLK PTLKQIRRPK NTILRFVVKF
FPPDHTQLME ELTRYLFALQ IKRDLACGRL ICNDTSAALM VSHIIQSEIG DFDETQSWQH
LLHNKYLPDQ DAIRDKITDC HRKHVGQTPA ESDYQLLEIA RRLEMYGVRL HPAKDREGTK
LSLSVAHTGV LVFQGYTKIN AFNWSKIRKL SFKRKRFLIK LRADPANAHH DTLEFAMASR
DCCKVFWKIC VEYHAFFRLF EEPKPKPKPI LFTRGSSFRF SGRTQKQIID YVKDSELKKV
PFERKHSKIL SNSGMSPQSS SFRSQVPKEV IRFFFLTTTG TDLYSPIVLF MAFYSFIFLG
KVVHFYRLFS PASDDSPLGS PHVVVNGNGS VNGQGMGSTG VLGPGQSPEG RQLSPLTSPL
LTEAGYVRND EEEEARRKKF PTDKAYFIAK ELLTTERTYL KDLQVITESF QSFVGKDEAF
PDSVQDLISA NYDPVHKFHQ GFLKEVEQRL AQWEGRSNAH IKGDYQRMGD VLLKNIQGLR
QLTIHLQKHS ECLVELERVC RSSRKVETLC RDFEQQRVCY LPFNIFLLRP LHRLLHYKLI
LERLCKHYPP THDDFRDSRA ALADISEMVL QLQGTMMKME NFQKLLELKK DLTGIDNLAI
RGREFIRLGC LSKLSGKGLQ QRMFFLFSDS LVYTSRGMTP SNQFKVHGQL PLYGMTIRES
EEEWGVPHSF TLFGQRQSVV VAASCASEME RWVEDIRMAI DLAEQSSSPS ADLLPAGVSD
NSKSLLEDSG AEQESEEELC GSRSSLERQG QRGNTTVHVC WHRNTSVSMV DFSVAVENQL
SGNLLRKFKN SNGWQKLWVV FTNFSLFFYK SHQDDYPLAS LPLLGYSVTV PAESENIHKD
YVFKLHFKSH VYYFRSESEY TFERWMEVIR SATCSTSHSL PSTRKDLY
//
