ID A0A3B4XLA6_SERLL Unreviewed; 626 AA.
AC A0A3B4XLA6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Estrogen receptor beta-like {ECO:0000313|Ensembl:ENSSLDP00000016997.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000016997.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000016997.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR002527}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000256|ARBA:ARBA00005413,
CC ECO:0000256|PIRNR:PIRNR002527}.
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DR AlphaFoldDB; A0A3B4XLA6; -.
DR Ensembl; ENSSLDT00000017601.1; ENSSLDP00000016997.1; ENSSLDG00000009163.1.
DR GeneTree; ENSGT00940000156116; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:InterPro.
DR GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IEA:InterPro.
DR CDD; cd07171; NR_DBD_ER; 1.
DR CDD; cd06949; NR_LBD_ER; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR021064; ER-beta-like_N.
DR InterPro; IPR028355; ER-beta/gamma.
DR InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR48092:SF30; ESTROGEN RECEPTOR BETA ISOFORM X1; 1.
DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR Pfam; PF12497; ERbeta_N; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF500102; ER-b; 1.
DR PIRSF; PIRSF002527; ER-like_NR; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR002527};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR002527};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR002527};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR002527}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 172..247
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 309..542
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 69632 MW; 03E07CE5ADA8FDC3 CRC64;
MGCGGANETS GSSPESGSDR GSNMPSSPGL LPTVYSPPLG MDNHTVCIPS LYTDSSHEYG
HGPLTFYSPP VLSYTRQPIA DNQSSPCPPL SPSAFWPSHS HTNVPSLTLR CTQPLVYNEP
NPHAPWLEPK PHSITAGSSI ISCNKLLGKR SEEGMERVNS SSCSSALGKA DMHFCAVCHD
YASGYHYGVW SCEGCKAFFK RSIQGHNDYI CPATNQCTID KNRRKSCQAC RLRKCYEVGM
MKCGMRRERC SYRGARHRRG GIHPRDPTGR GLMRVGHGPR AQRHLHLEAP LAPFAPLPQV
NHVHHTAMSP EEFISRIMEA EPPEIYLMED MKKPFTEASM MMSLTNLADK ELVLMISWAK
KIPGFLELSL ADQIHLLKCC WLEILMLGLM WRSVDHPGKL IFSPDFKLNR EEGQCVEGIM
EIFDMLLAAT SRFRELKLRR EEYVCLKAMI LLNSSDSPQT AEELESRNKM LRLLDSVIDA
LVWAISKLGL TTQQQTLRLG HLTMLLSHIR HMSNKGMDHL STMKRKNVVL VYDLLLEMLD
ANTSSSSSQT SASPSSDIFS DQHQYPPPSS HLQPGSDQTA TDADHTTVPP HRPAEAPLMD
THLQSLPLLS TPPSQNLVVA HMDSNE
//