ID A0A3B4XPB7_SERLL Unreviewed; 272 AA.
AC A0A3B4XPB7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=glycogenin glucosyltransferase {ECO:0000256|ARBA:ARBA00038934};
DE EC=2.4.1.186 {ECO:0000256|ARBA:ARBA00038934};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000018326.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000018326.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Glycogenin participates in the glycogen biosynthetic process
CC along with glycogen synthase and glycogen branching enzyme. It self-
CC glucosylates, via an inter-subunit mechanism, to form an
CC oligosaccharide primer that serves as substrate for glycogen synthase.
CC {ECO:0000256|ARBA:ARBA00043853}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-
CC glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP; Xref=Rhea:RHEA:23360,
CC Rhea:RHEA-COMP:14604, Rhea:RHEA-COMP:14605, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:46858, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:140573; EC=2.4.1.186;
CC Evidence={ECO:0000256|ARBA:ARBA00043655};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23361;
CC Evidence={ECO:0000256|ARBA:ARBA00043655};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-
CC D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+)
CC + UDP; Xref=Rhea:RHEA:56560, Rhea:RHEA-COMP:14606, Rhea:RHEA-
CC COMP:14607, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:140574; EC=2.4.1.186;
CC Evidence={ECO:0000256|ARBA:ARBA00043795};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56561;
CC Evidence={ECO:0000256|ARBA:ARBA00043795};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004964}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 8 family. Glycogenin
CC subfamily. {ECO:0000256|ARBA:ARBA00038162}.
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DR AlphaFoldDB; A0A3B4XPB7; -.
DR Ensembl; ENSSLDT00000018952.1; ENSSLDP00000018326.1; ENSSLDG00000014009.1.
DR GeneTree; ENSGT00940000161628; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0008466; F:glycogenin glucosyltransferase activity; IEA:UniProt.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02537; GT8_Glycogenin; 1.
DR InterPro; IPR002495; Glyco_trans_8.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR11183; GLYCOGENIN SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11183:SF164; GLYCOGENIN-1; 1.
DR Pfam; PF01501; Glyco_transf_8; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis {ECO:0000256|ARBA:ARBA00023056}.
FT REGION 215..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 30661 MW; A56B5124F030C37E CRC64;
MSGEAFVTLA TTDSYCMGAT VVARSLRRHG TTRGIVVMVT PNVSQQSRLA LESVFDEVIM
VDVMDSEDRL HLALLGRPEL GITFTKIHCW TLTQYSKCVF LDADTLVLCN VDELFERDEL
SAAPDPGWPD CFNSGVFVLR PSLHTHTGLM DHALQHGSFD GNARLHVQTD KLEATIVHFL
GPVKPWSSSS QRDDGSSHAT EQFATLWWKE YLSHTTPSTP GKQPSQDWKK PQQVPRPIEQ
LEHRRLWEAG RADYLGRDAF GNIQRKLDRF LD
//
