ID A0A3B4XPB8_SERLL Unreviewed; 1443 AA.
AC A0A3B4XPB8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Peroxidasin {ECO:0000313|Ensembl:ENSSLDP00000017580.1};
GN Name=PXDN {ECO:0000313|Ensembl:ENSSLDP00000017580.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000017580.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000017580.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 1841481.ENSSLDP00000017580; -.
DR Ensembl; ENSSLDT00000018189.1; ENSSLDP00000017580.1; ENSSLDG00000013799.1.
DR GeneTree; ENSGT00940000157666; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0140825; F:lactoperoxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd09826; peroxidasin_like; 1.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR034824; Peroxidasin_peroxidase.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF75; PEROXIDASIN HOMOLOG; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01463; LRRCT; 1.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR619791-2};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1443
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017200560"
FT DOMAIN 217..305
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 313..399
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 404..489
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 496..583
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1369..1427
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 1310..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1345..1372
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 1045
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 1443 AA; 161798 MW; 36D8C40DD8285E8E CRC64;
MALRAGQLFS PCLLAVALLS LASGPQFGLC CPSRCLCFRT TVRCMHLNLE TVPAVSPQTT
ILDLRFNKIK DIQPGSFRRL KNLNTLLLNN NHIRRIPRGA FEDLENLKYL YLHFNNIESL
EPESFTHLPK LERLFLHNNR ITQLVPGTFS HLQAMKRLRL DSNALNCDCE LLWLADLLKQ
YAESGNAQAA ATCDYPSRLQ GRSVATLTAE ELNCEVPRIT SEPQDVDVTS GNTVYFTCRA
EGNPKPQIIW LRNNNALNMR DDSRLNLLED GTLMIQDTRE TDQGVYQCMA KNVAGEVKTS
QVTLRYFGAP SRPSFVIQPQ NTEVLVGESV TLECSATGQP QPRVSWTKGD RTPLPNDARI
NITPSGGLFI QNVVQADGGQ YTCFASNNVD TIHATAYIIV QAIPQLTVTP QDQSVLEGHT
VDFPCEASGY PQPVIAWTRG GSPLPLDRRH AVLSSGTLRI TRVAAHDEGQ YECQAVSPVG
TVQTAVQLSI QQRVTPVFTN APRDLTVESG QDVQIPCSAQ GQPQPVLTWN KDGVQVTESG
KFHISPEGYL EVKDVGTADA GRYECVARNP IGYQVASMVL TVTVPAVSRE GDTFVSTSIE
QAIRNVDSAI ESTRRRLFDG QPRTPGELLA LFRYPRDPYT VEQARAGEIF EQTLLLIQNH
VNQGLMVDTN GTAFRYNDLV SPHFLDVIAN LSGCTAHRRF NNCSDICFHQ KYRSHDGTCN
NLQHPMWGAS LTAFERLLKS VYDNGFNLPR GATERLHNGF RLPLPRLVST TMIGTETITP
DDRYTHMLMQ WGQFLDHDLD STVAALSQSR FSDGQLCTQV CTNDPPCFPI QFPPNDPRQL
RSGARCMFFV RSSPVCGSGM TSLLMNSVYP REQINQLTSY IDASNVYGSS RHESEEIRDL
ASQRGLLRQG IIQRTGKPLL PFATGPPTEC MRDENESPIP CFLAGDHRAN EQLGLTAMHT
VWFREHNRIA TELLRLNPHW DGDTIYHEAR KIVGAQMQHI TYSHWLPKIL GEAGMKMMES
YAGYNPNINA GILNAFATAA FRFGHTLINP ILYRLDEEFQ PIPQGHISLH RAFFSPFRIV
NEGGIDPLLR GLFGVAGKMR VSTQLLNTEL TERLFSMAHA VALDLAAMNI QRGRDHGIPP
YNDYRTFCNL TSAQTFDELR NEIKNPSVRE KLQRLYGTPL NIDLFPALMA EDLVPGSRLG
PTLMCLLVTQ FKRLRDGDRF WYENPGVFTP AQLTQLKQAS LTRVLCDNGD NITRIQQDVF
RVAELPHGYG SCDDIPQIDL RMWQDCCEDC RTKGQFNALS YHFRGRRSAE HSYRENKPDD
KSPVNVTLTS KKSTEPSVTD FQDFVSDMQK TITSLRKQIK RLEARLRKTD CTDSEGRERT
DGERWKKDSC SICECRDAQV TCFVESCPPA KCKRPVKLKG ACCPVCLEQP DVDKRQEANT
HHD
//
