ID A0A3B4XQ72_SERLL Unreviewed; 390 AA.
AC A0A3B4XQ72;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Inhibin beta B chain {ECO:0000256|ARBA:ARBA00014337};
DE AltName: Full=Activin beta-B chain {ECO:0000256|ARBA:ARBA00032422};
GN Name=INHBB {ECO:0000313|Ensembl:ENSSLDP00000017820.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000017820.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000017820.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC secretion of follitropin by the pituitary gland. Inhibins/activins are
CC involved in regulating a number of diverse functions such as
CC hypothalamic and pituitary hormone secretion, gonadal hormone
CC secretion, germ cell development and maturation, erythroid
CC differentiation, insulin secretion, nerve cell survival, embryonic
CC axial development or bone growth, depending on their subunit
CC composition. Inhibins appear to oppose the functions of activins.
CC {ECO:0000256|ARBA:ARBA00002588}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3B4XQ72; -.
DR STRING; 1841481.ENSSLDP00000017820; -.
DR Ensembl; ENSSLDT00000018430.1; ENSSLDP00000017820.1; ENSSLDG00000014056.1.
DR GeneTree; ENSGT00940000159862; -.
DR OrthoDB; 3015718at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19405; TGF_beta_INHBB; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000381; INHBB_C.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF29; INHIBIN BETA B CHAIN; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00671; INHIBINBB.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..390
FT /note="Inhibin beta B chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017187576"
FT DOMAIN 272..390
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 390 AA; 43806 MW; BDD086645FA4E561 CRC64;
MSSCLFRLAL LVACVLSIRC TAASGTEAEA HTAPRDTCAS CGIAQPEDPE SGRLNVDFLE
AVKRHILSRL QMRERPNITH PVPKAAMVTA LRKLHAGKLR EDGRVEIPNL DGHPMSNEVL
EESSEIISFA EKDDIVTSKS SLFFLISSEG NQNLYVTQAT LWLYFKLLPS PVEVRPRRKV
TVKVYYQEPG LGSKWNLVEK RVELKRSGWH TFMLTDAVRL VFEKGDRRQN LDVRCEGCEA
AGVTPVLLNH NDESHRPFLV VQARQADNKH RIRKRGLECD GSSNLCCRQQ FYIDFRLIGW
NDWIIAPSGY FGNYCEGNCP AYMAGVPGSA SSFHTAVVNQ YRMRGMSPGS MNSCCIPTKL
STMSMLYFDD EYNIVKRDVP NMIVEECGCA
//
