ID A0A3B4XR80_SERLL Unreviewed; 589 AA.
AC A0A3B4XR80;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Merlin-like {ECO:0000313|Ensembl:ENSSLDP00000019091.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000019091.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000019091.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; A0A3B4XR80; -.
DR STRING; 1841481.ENSSLDP00000019091; -.
DR Ensembl; ENSSLDT00000019734.1; ENSSLDP00000019091.1; ENSSLDG00000014971.1.
DR GeneTree; ENSGT01020000230354; -.
DR OrthoDB; 5476297at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13194; FERM_C_ERM; 1.
DR Gene3D; 1.20.5.450; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR041789; ERM_FERM_C.
DR InterPro; IPR046810; ERM_helical.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23281:SF20; FERM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF20492; ERM_helical; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PIRSF; PIRSF002305; ERM; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT DOMAIN 14..304
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT COILED 315..464
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 518..552
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 68..71
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol)"
FT /ligand_id="ChEBI:CHEBI:57880"
FT /evidence="ECO:0000256|PIRSR:PIRSR002305-1"
FT BINDING 287
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol)"
FT /ligand_id="ChEBI:CHEBI:57880"
FT /evidence="ECO:0000256|PIRSR:PIRSR002305-1"
SQ SEQUENCE 589 AA; 69110 MW; B252A8F5DEA1AC3C CRC64;
MSILGLKKKQ PKTFKVKVIT MDAEMEFSCE VKWKGKDLFD LVCRTVGLRE TWFFGLRYTV
KDTYAWLKPE KRVLDQEVPK DSPITFHFLA KFFPEKVEEE LVQEITQHLF FLQVKKQILD
EEIFCSPEAS VLLASYAVQA KYGDYDPNFH KPGFLAQDEL LPKRVLMQYQ MTADMWEEKI
TAWYAEHRGI ARDEAEMEYL KIAQDLEMYG VSYFAITQNK RDTDLLLGVD AQGLHIYSPN
SKLNPNKSFP WSDIRNISYS EKEFTIKPLD KKKDVFKFYS SQLRVNKLIL QLCIGNHDLF
MRRRKVDSIE VQQMKAQAKE EKARKKMERQ ILAREKQMRE EAERAKEEME RRLFQLQDEA
RLANEALLRS EETADLLAEK AQIAEEEAKL LAHKAAEAEQ ERQRLEVTAM KTKEEKRLME
QKMREAEQLA VKLVEQSERR LKEADHLKQD LTEAKDAERR AKQKLLEITK TTYPLIAAYS
TPPAPPEAAD LGYESASTRL DFKDSDMKRL SMEIERERLE YMEKSKHLQD QLKELKSEIE
SLKLEEQQQQ AGLYGLHGEA RGYVQEPVYI PHSNRNSAYM SQMAFFEEV
//
