ID A0A3B4XTE0_SERLL Unreviewed; 1911 AA.
AC A0A3B4XTE0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Plexin-A2-like {ECO:0000313|Ensembl:ENSSLDP00000014783.1};
GN Name=PLXNA2 {ECO:0000313|Ensembl:ENSSLDP00000014783.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000014783.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000014783.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 1841481.ENSSLDP00000014783; -.
DR Ensembl; ENSSLDT00000015351.1; ENSSLDP00000014783.1; ENSSLDG00000011739.1.
DR GeneTree; ENSGT01050000244850; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF37; PLEXIN-A2; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..45
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 46..1911
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017208061"
FT TRANSMEM 1253..1275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..520
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1911 AA; 212586 MW; 466F23C0930DF0F0 CRC64;
MGTCLDKGWT NCGLTKGHGP LKVMSWPLAL WLLTLISVNQ KTTVGQTVST FQSERREWSL
NHLTVHQSTG ALYVGAVNRI YKLSANLTLL VSHDTGPEYD NKACYPPLIV QPCSEPLAST
DNVNKLLLID YSHNRLLACG SLYQGVCKLM RLDDLFILVE PTHKKEHYLS SDNQTGTMYG
VVVPSQGQDA TLYIGTAVGG KQDYFPTISS RKLPRDPESS AMLDYELHTD FVSSLIKIPS
DTLALVPHFD IYYIYGFASG SFVYFMTVQP ETPENGMPAG GSPGDLFYTS RIIRLCKGDT
KFHSYVSLPV GCVHRGEEYR LLQAAYLAKA GRVLAKSLNI SAQEDVLFAV FSKGQKQYHD
PPDHSVLCVF TIQDINTRIK ERLQSCYQGE GNLELHWLLG KDVQCTKAPV PIDDHFCGLD
INQPLGGSQL VSGRTVFTES RDRLTSVTSY VYNGHSVVFL GTRSGRLKKI RVDGPLEGGV
LYETVTVMKD SGTILRDMAF SLDRNSLYVM SDNQVAQVPV EACEQYGTCA ECLSSGDPHC
GWCVLYNMCS RRDRCQRAEE TFRFATVIDR CVKVIAHPDS IAVSAHSVPL LLEVNNVPDL
SAGITCSFGQ QAQVEGHVKG NRVMCLSPAG KEVPQIPEGQ DWAGVELRLN SKETGQMVAS
TEVKFYNCST HQTCLSCVNS TFRCHWCKYR NLCTHDPSSC SFQEGRVNAS EDCPQLLHSG
EILIPAGEVR PITLRARNLP QPQSGQRGYE CVVHVQGVSH RVTALRFNST SVQCQNSSYM
YEGVKISDLA VDLSIVWNGN FIIDNPEKIK VHLYKCSAQR DSCGMCLRAE RKFQCGWCSG
EGRCTMKQHC PPISPYASRW LDLSARNVKC TNPRITEVSP VAGPLEGGTL VTIQGLNLGL
SFSELEGNVE VAGVQCTPQE EGYITAEQIV CEMAAAPKRS AAGPVKLCVG ECRPELRAQS
SQFYSFVTPS MLALTPGRGP ESGGTKVTIV GENLGAGSTV TVYFGNQTCE LYRRTTSEIV
CFSAPSVTGA GPVQVGLSVD RAKVPGSLAF EYIEDPTVQR IEPLWSITSG HTTLTVTGTN
LDVVQEPRVR VKYAGHESVN VCKVLNTTTI SCFAPSLKAE YNTDQETIKH VDEFGFVFNN
VQALLTYNST SFVYYPNPYL EPLSLSGVLE QKPGAPIILK GRNLVPSASG GARLNYTVLI
GDTPCSLTVS DTQLLCEPPN LTGQHKVLVQ VGGLHISPGE VHIRSDSLLT LPAIFSIAAG
GGLLLIIVII VLLAYRRKSH ENDLTLKRLQ MQMDNLESRV ALECKEAFAE LQTDINELTS
DLDRAGIPYL DYRTYAMRVL FPGIDDHPVL RELEVPGSGQ ANVEKALKQF AQLVNNKVFL
LTFIRTLELQ RSFSMRDRGY VASLIMTALQ GRLEYATDIL KHLLSDLIER NLESKNHPKL
LLRRTESVAE KMLTNWFAFL LHKFLKECAG EPLFMLFCAI KQQMEKGPID SITGEARYSL
SEDKLIRQQI EYKTLTLSCV NPDNENSPEI PVKVLNCDTI TQVKEKILDA VYKNMPYSQR
PRAADMDLEW RQGRTARVVL QDEDITTKIE SDWKRLNTLM HYQVSERCVV ALVPKQMSSF
NIPSSASFPR SISRYGVDVP FRSTPTSPDS PHSRVPMLTP DLESGVKVWH LVKNHDHGDQ
KEGERGSKMV SEIYLTRLLA TKGTLQKFVD DLFETLFSTV CRGTALPLAI KYMFDFLDEQ
ADRHGIHDMD VRHTWKSNCL PLRFWVNVIK NPQFVFDIHK SSITDACLSV VAQTFMDSCS
TSEHRLGKDS PSTKLLYAKD IPHYKSWVER YYADINRLPA ISDQDMNAYL AEQARLHSSE
FNVLSALHEI YTYVSKYSQE IIEALEQDEQ AQKQKLAYKV EQIISVMSAE S
//
