ID A0A3B4XTR4_SERLL Unreviewed; 915 AA.
AC A0A3B4XTR4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=VPS10 domain-containing receptor SorCS3-like {ECO:0000313|Ensembl:ENSSLDP00000021845.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000021845.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000021845.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A3B4XTR4; -.
DR Ensembl; ENSSLDT00000022559.1; ENSSLDP00000021845.1; ENSSLDG00000016863.1.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF45; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3 ISOFORM X1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00089; PKD; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 860..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 585..652
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 547..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 915 AA; 103343 MW; 60513F9397E49FF3 CRC64;
IMMLSDPEVE SAVLISSDEG ASFEKHPINF NILSLLFHPA QENWILAYSH DSKLYSSMDF
GRKWQLVHDN VMPGRFYWAV MGLDKESDVV HIETRIAKGR AQYVKCRAQR CTDGNRQYLF
PGYVDTNSLV VQDEYVFTQV TKSGRASYFV SYMRESFKRM KLPKYCLPKD MHIISTDEKQ
VFAAVQEWNQ NNTYSLYISD SPGVYFTLSL ENLRTSRGPA GNLLVDFYKV EGINGMYLAN
KLVDNHIKTF ITYNKGQTWA LLPGPSTDVA GNNLHCILPF CSLHLHLEML ENPYTSGPIT
SKKSVPGIIV ATGNIGTELS STNLGMFITS DAGNSWRQIF DEEHNIWFLD NGGALLAVLH
AATPIRHLWI SLDEGKKWDR HSFSLAPLYV DGVLMEPESD NHIITFFGHF SHRSEWQLIK
IDYKGLFSRR CMDGDYQTWH LHNKGELCVM GERQIFMKRR PGNRCMLVQD YSRIYSSEPC
LCTTYDFECD YGWERQADGK CSPAFWFNPN GAAKTCSSSQ SFLNSTGYRK VLSNNCKEAG
RNVYSPRRQA CRPRPPRGLR LSTNQGELSA PVGSNVTFMV YLEDGDSLRT SIQLDFGDGI
KITYSNLSRT DDGIMHIYRT TGIYRVTASA ENSQGSDSST LFLHITSPVE RVYLSVPIVA
IRGKEANLTA VVWPSHTRTL TFFWWFDNSS EPIITLEGSI SYTFQREGKN KVTVQVASGS
TVMQDSKVIT VKEFFRSLLL SFSPALDEHN PDIPEWREDI GRVVRAALSQ VHGVPILLVS
LYPGLPTTAE LFILPDEHTA SEHKRGSEEA LETISDIFVT ALNQGLIQFE LKADTRIIVY
MTQQTLAPLV DSNSIHSGSA MLMLLTVVFV GLAAFFIYKF KRYLSSLERH HECSMSHTAR
TTSASAQLPD ITMTS
//
