ID A0A3B4XUA6_SERLL Unreviewed; 675 AA.
AC A0A3B4XUA6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Histone-lysine N-methyltransferase SETDB2 {ECO:0000256|ARBA:ARBA00040299};
DE EC=2.1.1.366 {ECO:0000256|ARBA:ARBA00039052};
DE AltName: Full=SET domain bifurcated 2 {ECO:0000256|ARBA:ARBA00042995};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000019230.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000019230.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-
CC methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]
CC + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60288, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15541, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961,
CC ChEBI:CHEBI:61976; EC=2.1.1.366;
CC Evidence={ECO:0000256|ARBA:ARBA00036635};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR AlphaFoldDB; A0A3B4XUA6; -.
DR STRING; 1841481.ENSSLDP00000019230; -.
DR Ensembl; ENSSLDT00000019873.1; ENSSLDP00000019230.1; ENSSLDG00000015081.1.
DR GeneTree; ENSGT00940000158209; -.
DR OrthoDB; 2877903at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB2; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 324..385
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 388..628
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 639..655
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 103..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..482
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 73775 MW; D8A770ACD0062F70 CRC64;
MFLSPLDMEE EALDAQDVER AKAFWAGEDV DQAFDGVFEY LNHLKRVLKK NTATDKELVQ
ALKVLETLDL SAPVSSQDAS VVQVVIGSGQ VLLPADFSHR SPPSPSFSSP CTSPAPPSNS
LSSSSVPPPG RDELLPPLLP VQLQYQPHPC CKACLPSLSS MPQCAPPFWG QNPLKAPLLC
GFKRLSAMPL ASPRGGGTWD GKGVEPAVSE EVEEEAVEDW DVVYKAPCGQ SLRNHDDVMR
FLLASESYDV LQVDFFTFNP SVRLDPPVVP GPRRPELDLS RGSEPTPVEL CGGDGGARPA
DFRYRRDRWP HGCFLSRSPM LFDSCCDCTD GCTDAQRCTC IAMTRGGRSY THHRLTQPVA
SGLYECGPWC SCDRARCQNR LVQRGIRIRL QVFQTEDRGW GVRCRDDLDR GTFVCIYAGV
ILQRVQSPAE LPPPKLTRAE LPSDDEVEVV TEWLAPPVLE GRSKLLESPP PLSPPNSPPL
HVPVIQRPAD SNSTTAAVQD RDKGQTVLVG GPEASSPSAG DQSQSKEKND ATPTASPAAA
AVHSVNGTKM ETKERERKSL KRAATVEDVY FLDASKEGNV SRFINHSCRP NLFIQNVFTD
THDPGFPVIA FFTNRVVKAG TELTWNFSSD TQTASLRKQE VPCLCGSDGC RGQFTIKESL
CDVCEVKGQE AIKAK
//