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Database: UniProt
Entry: A0A3B4XUA6_SERLL
LinkDB: A0A3B4XUA6_SERLL
Original site: A0A3B4XUA6_SERLL 
ID   A0A3B4XUA6_SERLL        Unreviewed;       675 AA.
AC   A0A3B4XUA6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Histone-lysine N-methyltransferase SETDB2 {ECO:0000256|ARBA:ARBA00040299};
DE            EC=2.1.1.366 {ECO:0000256|ARBA:ARBA00039052};
DE   AltName: Full=SET domain bifurcated 2 {ECO:0000256|ARBA:ARBA00042995};
OS   Seriola lalandi dorsalis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000019230.1, ECO:0000313|Proteomes:UP000261360};
RN   [1] {ECO:0000313|Ensembl:ENSSLDP00000019230.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-
CC         methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]
CC         + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60288, Rhea:RHEA-
CC         COMP:15538, Rhea:RHEA-COMP:15541, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961,
CC         ChEBI:CHEBI:61976; EC=2.1.1.366;
CC         Evidence={ECO:0000256|ARBA:ARBA00036635};
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR   AlphaFoldDB; A0A3B4XUA6; -.
DR   STRING; 1841481.ENSSLDP00000019230; -.
DR   Ensembl; ENSSLDT00000019873.1; ENSSLDP00000019230.1; ENSSLDG00000015081.1.
DR   GeneTree; ENSGT00940000158209; -.
DR   OrthoDB; 2877903at2759; -.
DR   Proteomes; UP000261360; Unplaced.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 2.170.270.10; SET domain; 2.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR   PANTHER; PTHR46024:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB2; 1.
DR   Pfam; PF01429; MBD; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF54171; DNA-binding domain; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          324..385
FT                   /note="Pre-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50867"
FT   DOMAIN          388..628
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          639..655
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          103..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          464..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        468..482
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..501
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..532
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   675 AA;  73775 MW;  D8A770ACD0062F70 CRC64;
     MFLSPLDMEE EALDAQDVER AKAFWAGEDV DQAFDGVFEY LNHLKRVLKK NTATDKELVQ
     ALKVLETLDL SAPVSSQDAS VVQVVIGSGQ VLLPADFSHR SPPSPSFSSP CTSPAPPSNS
     LSSSSVPPPG RDELLPPLLP VQLQYQPHPC CKACLPSLSS MPQCAPPFWG QNPLKAPLLC
     GFKRLSAMPL ASPRGGGTWD GKGVEPAVSE EVEEEAVEDW DVVYKAPCGQ SLRNHDDVMR
     FLLASESYDV LQVDFFTFNP SVRLDPPVVP GPRRPELDLS RGSEPTPVEL CGGDGGARPA
     DFRYRRDRWP HGCFLSRSPM LFDSCCDCTD GCTDAQRCTC IAMTRGGRSY THHRLTQPVA
     SGLYECGPWC SCDRARCQNR LVQRGIRIRL QVFQTEDRGW GVRCRDDLDR GTFVCIYAGV
     ILQRVQSPAE LPPPKLTRAE LPSDDEVEVV TEWLAPPVLE GRSKLLESPP PLSPPNSPPL
     HVPVIQRPAD SNSTTAAVQD RDKGQTVLVG GPEASSPSAG DQSQSKEKND ATPTASPAAA
     AVHSVNGTKM ETKERERKSL KRAATVEDVY FLDASKEGNV SRFINHSCRP NLFIQNVFTD
     THDPGFPVIA FFTNRVVKAG TELTWNFSSD TQTASLRKQE VPCLCGSDGC RGQFTIKESL
     CDVCEVKGQE AIKAK
//
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