ID A0A3B4XWJ8_SERLL Unreviewed; 874 AA.
AC A0A3B4XWJ8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha-1C {ECO:0000256|ARBA:ARBA00024095};
DE AltName: Full=Voltage-gated calcium channel subunit alpha Cav1.2 {ECO:0000256|ARBA:ARBA00030570};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000020056.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000020056.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma, T-tubule
CC {ECO:0000256|ARBA:ARBA00024012}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU003808}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034112}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1C subfamily. {ECO:0000256|ARBA:ARBA00024028}.
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DR AlphaFoldDB; A0A3B4XWJ8; -.
DR Ensembl; ENSSLDT00000020726.1; ENSSLDP00000020056.1; ENSSLDG00000015301.1.
DR GeneTree; ENSGT00940000156127; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030315; C:T-tubule; IEA:UniProtKB-SubCell.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.250.2180; -; 1.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005451; VDCC_L_a1csu.
DR InterPro; IPR002077; VDCCAlpha1.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF10; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 2.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01635; LVDCCALPHA1C.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU003808};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 49..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 299..333
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 419..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..849
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 96618 MW; B700CB82AE02666F CRC64;
MFGLQNSEEN ARISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIVML
FFIYAVIGMQ MFGKIALQDN TQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLACSPNRP
CEKGSTNENS TTNEECGSQF AIIYFVSFYM LCAFLIINLF VAVIMDNFDY LTRDWSILGP
HHLDEFKRIW AEYDPEAKGR IKHLDVVTLL RRIQPPLGFG KLCPHRVACK RLVSMNMPLN
SDGTVMFNAT LFALVRTALR IKTEGNLEQA NEELRAIVKK IWKRTSMKLL DQVVPPAGDD
EVTVGKFYAT FLIQEYFRKF KKRKEQGLVA KVPPKTALSL QAGLRTLHDI GPEIRRAISG
DLTVEEELDK GLKEPVSAAS EDDIFRRTGG LFGNHVNYYN QSDGRGSFPQ SFTTQRPLHI
SQKGSPCEGE SPSHEKLMDS TTFTPSSYSS SGSNANINNA NNTGMAGVAT QGISRFPSPS
ISTVDGHTGQ PLTPILLPRS ACRLPIIRRG EGSTEETYDE SYGEDREYHE DDHSLSSDML
VYHDDTCKQL TPMEEGEEVE DRRGGGWQSP RRVFLCPTSL GRRSSFHLEC LRRQSRPDVS
QKTAVPLHLV HHQALAVAGL SPLLRRSHSP TLFSRLCSTP PATHGSDASY QRVPSLRLEG
SNSHEKLNTS LPSVNCGPSP TPSVSVSNQR APRPVSLTVP SLLGKDSSTL CHGSAGSLVE
AVLISEGLGH FAQDPSFIEA TKAELADACD MTIEEMEHAA NNILNGNTTT NHSPNGNLLP
FHTAAAATHR DRVVSLSPSE GGGEAGGSRG SIHGPSSVEE RQELLAGGRG REEEEEEAEE
REEGHHRSSV VIGAARQRNS GLLEDEDMEC VTSL
//
