ID   A0A3B4Y3A5_SERLL        Unreviewed;      1276 AA.
AC   A0A3B4Y3A5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Rho guanine nucleotide exchange factor 10-like protein {ECO:0000313|Ensembl:ENSSLDP00000025320.1};
GN   Name=ARHGEF10L {ECO:0000313|Ensembl:ENSSLDP00000025320.1};
OS   Seriola lalandi dorsalis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000025320.1, ECO:0000313|Proteomes:UP000261360};
RN   [1] {ECO:0000313|Ensembl:ENSSLDP00000025320.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4Y3A5; -.
DR   STRING; 1841481.ENSSLDP00000025320; -.
DR   Ensembl; ENSSLDT00000026109.1; ENSSLDP00000025320.1; ENSSLDG00000019703.1.
DR   GeneTree; ENSGT00940000153798; -.
DR   Proteomes; UP000261360; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF16; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          321..508
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1122..1162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          491..518
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        11..31
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1137..1158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1276 AA;  140400 MW;  853B00E57EEFC4F0 CRC64;
     MSTAISQQPP KEDEEEEDEE QGEEFVFEDS TDEEKLPDSK GISSACVSSV QASKKEDSET
     AQRDSTQLPK TSPPAGQEGI PTKDVESIST ADVPVTESPS WASAADEPST SAPCEGEELR
     GLPVAPADAG DHSKKNVKES TGSRDISEAG PQTAEASEVI YDDVPSEDPL SPDEDMIYED
     VQRDSGPVNA DNGWSSSEFE SYDEQSDNEA KIPTRSKLSP EVRRLRERCA RTKRELAMRL
     SGKHNYDIKV QQLMKAAKSG TKDGLEKTKI AVMRKVSFLQ RKDQLEEEDD AGYLDVTVSE
     MKHPPPQLSP MPEGLTSHQV VRRHILGSII QSERSYLESL RRILQEYHRP LMEADPRILS
     PRKIRPIFYR IREITQCHSM FQIALASRVA EWDSSEKIGD LFVASFSKSM VLDVYSDYVN
     NFTSAMALIK KACMSKPAFL EFLKKKQSSS VDRITLYGLM VKPIQRFPQF ILLLQDMLKN
     TPKGHVDRLP LQLALTELEM LAEKLNEQKR VADQITETQQ LARSVSDRLL SKQLNSEQGS
     LVLCETLIET VYGERGQVLK SKERKVFLFD DVLICANINV KGPPDISSLV PIGPKYTMKW
     SAPLQQVQVV EVGQESSQSK DTFFQQSGAK RPSSVCSSGK AILGPPRLYQ ELQELQHDLS
     VVEEVTLLVG TLQGTYQNLN TTVAQDWCLA LQRLIRIKEE QIQSANKCRL RLQVPGRPDK
     SGRPVSFMVV FNTPNPLSKI SWVNRLHLAK IALREENSPG WLCGEDDGKT MAPLWCPLLS
     CHMPVFAMKS PERKLEAALH NPVHCALLGF SAASTSLPQG YLWVAGGGEG SQGQIEIFSL
     NRPMPRAVKS LQVGSAVRCL EYVPEPSHAE EVEAGVHKAP SGISSNICVG LDDGRILVYG
     SVDTAAQCLL TLRNPEGCPV LCLKHSSRFL FAGLRNGTMM VYGRNNSDDL WEPDSCRCVN
     LGSEPVRTLL VLDDSVWASW GNSVTVIDIS SLATQKFEVH PEPMVSVTHM ACAGGGVWMA
     FSEGSSIRLF HTETLELLQE INISTRSTLL NTGQKSMRVT SLLICQGLLW VGTAQGLIIT
     LPVPKLEGIP KITGKGMVSL NSHCGPVDFL VATTSTLSPE LLKRDSVGDS PDSACGGEDR
     SDTSSQESLQ QSSSYQGEGR GKGRGVLLQY KLRSTSGLPG RPLTAQGDEA LDSSLESLEH
     SVEDGSIYEL SDDPEMWVRG RPCERDGGRR DRVISAAVIS GGKGFRRLKE GAPAGTRTSV
     EGLENILMVW QLPLTV
//