ID A0A3B4Y881_SERLL Unreviewed; 2357 AA.
AC A0A3B4Y881;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000027055.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000027055.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR STRING; 1841481.ENSSLDP00000027055; -.
DR Ensembl; ENSSLDT00000027889.1; ENSSLDP00000027055.1; ENSSLDG00000020976.1.
DR GeneTree; ENSGT00940000158908; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR CDD; cd21246; CH_SPTB-like_rpt1; 1.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 8.
DR Gene3D; 1.20.58.60; -; 13.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF248; SPECTRIN BETA CHAIN, ERYTHROCYTIC; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 17.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00033; CH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 17.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 15.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR002297}; Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 54..158
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 175..280
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 2199..2309
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 2104..2123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2132..2189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2306..2357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 459..493
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 885..919
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1398..1445
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1566..1593
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2104..2122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2357 AA; 272730 MW; 536B4513F835714D CRC64;
MTSTTDFDNV EITQQYSHIN TRFDLCDEEL DNDNSSARLF ERSRIKALAD EREAVQKKTF
TKWVNSILSR VGCRISDLYL DLRDGRMLIK LLEVLSGERL PKPTKGRMRI HCLENVDKAL
QFLKEQRVHL ENMGSHDIVD GNHRLILGLI WTIILRFQIQ DIIVETGQAD QKETRSAKDA
LLLWCQMKTA GYPNVNITNF TTSWKDGMAF NALIHKHRPD LVDYNSLKRS NPTHNLQNAF
NVAEQKLGVT KLLDPEDVFT ENPDEKSIIT YVVAFYHYFS KMKQLAVEGK RVGKVLDHAI
ETEKMIDKYE TLASDLLTWI EQTIIVLNNR KLANSLAGVQ QQLQAFNTYR TVEKPPKFQE
KGNLEVLLFT IQSRMRANNQ RVYTPKEGAL VADINRAWER LERAEHERER VLRDELIRQE
KLEQMARRFD RKAAMRETWL MENQRLVAQD NFGYDLPAVE AAKKKHDAIE TDIAAYEERV
QALVDISKEL ESERYHDAKR IDARKDNILR LWDYLQELLK ARRARLDKNL TLQRIFQEML
HIISWMDDMK ARLLSPDFGK HLLEVEDLLQ KHALVENDIA LQADRVHSAS AAALKFANGD
SYKPCDPQVI RDRVQHLDLC YQELCALAAQ RRAHLEQSRR FWYFLWEVTE LESWIREKEH
IFSSLDYGKD LTSVLVLQSK HSAFEDELGA RRANLEQVLA EGEKMIQAKH FGSPKVQECM
DDIRRQWQQL EELAAFRKQN LQDTQRFFQF QGDADELKAW LLDAKRLMSS EDVGHDEYTT
QRLLKKLNDL RNEAIKNGAT IDALSKQANA LPEELQNTPD IQRRLKDIKD LYMELMSLAD
LRQKKLDDTM ALYTIFSETD ACELWMGQKE TWLVDLEVPE KLEDLEVVQN RLSILAQDMA
NVQSRVDDVN KAVKQLEDSR HPRTKEVKEC QTRLNKRWEA FKAMVEDKKR KVDSAVSLHN
YGLECDETET WIKDKTRVIE STQDLGNDLA AVMTIQRKLF GMERDLAAID TKLTFLRKEA
DQLAKDHPEN ADDILARRGE LDAAWDTLRK TLKDREDSLG EVSKLQTFLQ DMDDFQSWLF
KTQKAVASEE MPATLPEAEE QLSLHDAVRE DIGNHEEDFH RVRDTGAQVM QGQEDDPQYQ
QLEQRLKGMD RGWVELQKMW DSRKNFLDQG VGFQQFMRDG KAVEAILNNQ EYTLAHIDKP
DTLAGAEKAL KKHEDFVSTM EANEDKIDGA LQGGQRLVDS NNLYSGKVQE KMDSIKDRHD
KNNRRAQEVS EKLRDNRDLQ HFLQNTQDLT VWINEKMLTA QDTSYDEARN LHSKWLKHQA
FMAELASNKD WLNNIDQEGQ ELMESKPEFE PIVKERLAKL HELWDKLEST TQEKARLLFD
ANRSELFDQS LADMKKWLGE LQQQLQSGDE DVKDLTNANI LLKKHQMTEN QVRGRARELE
ELQEAVRQHG GGREDQPELE AEQQALQRDF QQLLTPLAER KGKLEAAKAV HQFYRDLADE
LLWIEERMPL AMSEEHGHNL QTVQMLLNKN QTLQREIEGH QPRVDEVLER GRRMAAAANA
EGRPEADRIT DQLKELEEAW ARLQDEMAKR RERLNGSNLA QQYYNDADEA EAWIGEQELY
MIADEKAKDE QSAMLMLKRH TILKRAVDDY ADSIQKLADR AQKMFAEDHP DGEEIIRRQG
QVDKQYAGLK ELAEDRRRKL DHTYHHFLLS REVEDLEHWI AERDVVASSQ EMGQDLDHVT
LLRDKFRDFA RETGMVGQER VDFVNQTIDE LIEAGHTEAA AMAEWKDGIN DSWADLLELI
DTRAQLLTAS YELLKYFDDG KELVAQIHEK QKELPDDVGE DFSKAESFHR MHAAFERDIT
ALGKQVQQFQ ETAARLHAQY AGDRAVAIQA TEQEVVEAWK GLLDACDGRR AQLVDTAEKF
RFFTMVRDLM AWMESIIQQI ETQEKPRDVS SVELLQKYHQ GIRSEIEARG VKFSDCMDLG
KALLTRKHRD SAEIKEKLVQ LMEKRKEMMF KWDDRWDWLR LLLEVCQFAR DASVAEAWLI
AQEPYVTSRD LGHTVDEVEK LLKRHEAFEK STATWEERFS ALERLTTLEL LELRKQQQEM
EQFIKDEQRS DKESRREDTG FVEESSQLYT IEEQTLSGSG AIEPSSGLLE GAAGDSTVPI
ESEMRESGSL ELEPSVSVVT PREPERAATM PVEPLRAHTV LLEGTLGRKH DVEGSGKKAS
NRSWNNLYCV LKPGQLSAYK DAKSFGHGTT YHGEDPQSLS NASWEILTTY KKKKHVAKLR
LGDGSEYLFQ CKDEEELQRW SQAMDKAVQP LAAEEASGPS GAKAHSLPPP SSSAALPEPS
SAKKDKEKKF SRFAKKK
//
