ID A0A3B4YEA6_SERLL Unreviewed; 1141 AA.
AC A0A3B4YEA6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Solute carrier family 12 member 2 {ECO:0000313|Ensembl:ENSSLDP00000026501.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000026501.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000026501.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3B4YEA6; -.
DR Ensembl; ENSSLDT00000027317.1; ENSSLDP00000026501.1; ENSSLDG00000018176.1.
DR GeneTree; ENSGT00940000155742; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 137..190
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 225..726
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 735..1141
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..919
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 124656 MW; 71C1ABF22C0919E6 CRC64;
MTSREVAHSG SPPFSDADSP DAGQRPPGPT PSQSRFQVDL VAEAAGAAED KSPNSDASSS
VPSGEKAPQE CPGADSGAGG EEAKGRFRVV NFADPSGAGS AASPEAPPAE GLQNGDTVMS
ETSLHSSTCG QHHYHYDTHT NTYYLRTFGH NTIDAVPNID FYRQTAAPLG EKLIRPTLSE
LHDELDKEPF EDGFANGDEL TPAEEAAAKE AAESKGVVKF GWIKGVLVRC MLNIWGVMLF
IRMSWIVGQS GIALSCLIVA MATVVTTITG LSTSAIATNG FVRGGGAYYL ISRSLGPEFG
GSIGLIFAFA NAVAVAMYVV GFAETVVELL GADALMTDQT NDIRIIGTIT VILLLGISVA
GMEWEAKAQI FLLIVLITAI INYFIGTFIP VKAKESVGFF GYDSAIMWEN MGPNFQGETF
FSVFSIFFPA ATGILAGANI SGDLADPQLA IPRGTLLAIL ITGIVYLGVA VSTGSCIVRD
ATGNVNDTLS SQFITNCTDA ACKFGYDFSS CKNTKCDYGL QNDFQVMSMV SGFGPIITAG
IFSATLSSAL ASLVSAPKVF QALCKDNIYP GLGMFAKGYG KNNEPLRGYI LTFGIALAFI
LIAELNTIAP IISNFFLASY ALINFSVFHA SLANSPGWRP SFKYYNMWVS LAGAVLCCVV
MFVINWWAAL LTNVIVLGLY IYVSYKKPDV NWGSSTQALT YHQALTHTLH LSGVEDHIKN
FRPQCLVMTG YPNSRPALLD LVHSFTKNVG LMICGHVRTG YRRPNFKDLA TDQSRYQRWL
LKNETKAFYT PVFAEDMRQG SQYLLQAAGL GRLKPNTLVL GFKNDWRDGD MMNVETYISM
IHDAFDFQFG AVILRLKEGL DVSHIQGQVM KDVIVSIDTS KDSDADSSKP SSKATSLQNS
PAIQKDDDDD GKAPTQPLLK KDKRSPTVPL NVSDQRLLEA SQQFQKKQGK GTVDVWWLFD
DGGLTLLIPY LLTNKKRWKD CKIRVFIGGK INRIDHDRRA MATLLSKFRI DFSDITVLGD
INTKPKKEHV TAFEELIEPY RLKEDDMEQE AAERLKNSEP WRITDNELEL YRAKTNRQIR
LNELLKEHSS TANLIVMSLP LARKGAVSSA LYMAWLEVLS KDLPPILLVR GNHQSVLTFY
S
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