ID A0A3B4YG89_SERLL Unreviewed; 568 AA.
AC A0A3B4YG89;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Estrogen receptor beta-like {ECO:0000313|Ensembl:ENSSLDP00000028622.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000028622.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000028622.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR002527}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000256|ARBA:ARBA00005413,
CC ECO:0000256|PIRNR:PIRNR002527}.
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DR AlphaFoldDB; A0A3B4YG89; -.
DR Ensembl; ENSSLDT00000029468.1; ENSSLDP00000028622.1; ENSSLDG00000020964.1.
DR GeneTree; ENSGT00940000156116; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:InterPro.
DR GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IEA:InterPro.
DR CDD; cd07171; NR_DBD_ER; 1.
DR CDD; cd06949; NR_LBD_ER; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR021064; ER-beta-like_N.
DR InterPro; IPR028355; ER-beta/gamma.
DR InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR48092:SF12; ESTROGEN RECEPTOR BETA; 1.
DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR Pfam; PF12497; ERbeta_N; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF500102; ER-b; 1.
DR PIRSF; PIRSF002527; ER-like_NR; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR002527};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR002527};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR002527};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR002527}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 169..244
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 289..525
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 256..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 63868 MW; 575121E8CBA956F8 CRC64;
VRLIHQSENS PCELQQSIAM AAASTEKDQP LLQLQEVDSS RILSPIFGSS SPGLSSQPIC
IPYPYTDLGH DFTTIPFYSP TTFSYASPSI SDCPSVHESL SPSLFWSSRD HMGPPIPLQS
SQVQPQRGQP IESVWVEQTP RDRVLTTSVR RRSQESEDGV VSLSGKSDLH YCAVCHDYAS
GYHYGVWSCE GCKAFFKRSI QGHNDYICPA TNQCTIDKNR RKSCQACRLR KCYEVGMTKC
GMRKEQGGYR NPKTRRLTRW SSQSRTNGPK AVTAPAEGSL GNPQWPTLTS RQLIERIMEA
EPLEIYLMMD MSRPLTEANV MMSLTNLADK ELVHMISWAK KIPGFVELSL MDQVHLLECC
WLEVLMMGLM WRSVDHPGKL IFSPDFSLSR EEASRVQGFT EIFDMLIAAT SRVRELKLQR
EEYICLKAMI LLNSNMCLSS SEGSKELQSR SKLLCLLDAV TDALVLAIAK TGLTFRQQYT
RLAHLLMLLS HIRHISNKGM DHLHWMKMKS MVPLYDLLLE MLDAHIMHSS RLPHQAPQQE
SADQKPGARP AAPACPAAPP ADPADHKR
//
