ID A0A3B4YIJ5_SERLL Unreviewed; 999 AA.
AC A0A3B4YIJ5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Protocadherin alpha-C2-like {ECO:0000313|Ensembl:ENSSLDP00000022779.1};
GN Name=PCDHAC2 {ECO:0000313|Ensembl:ENSSLDP00000022779.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000022779.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000022779.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3B4YIJ5; -.
DR Ensembl; ENSSLDT00000023514.1; ENSSLDP00000022779.1; ENSSLDG00000017781.1.
DR GeneTree; ENSGT00940000160554; -.
DR OrthoDB; 4259465at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF119; PROTOCADHERIN ALPHA-C2; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..134
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 135..243
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 244..351
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 352..455
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 456..565
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 578..678
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 742..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 999 AA; 108564 MW; CE9E1CE3DBE4DCBB CRC64;
MAVAGICNWI GNNVPFYFVI FSLFCGLSFG QLRYSITEEL ENGALVGDLA HDLGLDIRKL
ATRKIKVTSN SGKRYVIVNP KNGKLLVNER IDREALCDLS STCLINLEVL VENPTEVHHI
EVEIVDANDN APQFPRDEYQ LEITESALPG SRYPIENAQD PDIGSNSVRM YQLSTNDHFA
LVSNKPSLNT KHIELVLKKP LDREQTPYHQ LILSAVDGGT PEKTGTAKIN VRVLDSNDNV
PLFDSSVYKV KLLENSPKDT LVIKLNATDL DEGTNGEVYY SFSSYTPERV RQMFSMDTNT
GEIRVRNNVD YEETNSYEMY IQAMDKGPGA VAAHCKVVVE VVDVNDNVPQ IVLSSLSSPV
REDARADTVV ALISVTDRDS GANKQVSLEI PAGLPFKIKS FRNYYTLVTS AFLDRETTDA
YNVTLSATDG GNPPLSSQKT IQVDVADVND NPPRFEQTSY TVYVAENNAP GASLCTVKAQ
DADIKENARI TYTVLNDNNH GIPVTSYVSV KADTGEAYAL RAFDYESLRE FHFQVKAQDG
GIPPLSRVAT VYIYIMDQND HAPLIVNPPG NGTRSLETVQ KNAEPGALVT KVVAYDADAG
PNAWLVYVLE TATDLDLFKV HEHTGEIRTT RRILEDNSTS FALTVVVKDH GQPALTSTAT
INVAVMEVPP KVVPDPKRII RPHSTLLFSN VTLYLIVALS ATTFVFLVTV VVLAIVRCHA
YCTQPGSCSP CCVSQKPPPD GGSSSVSAGG AGGGAAGGQP NNNVVLRRDL KVEPHYIEVR
GNGSLTKTYC YKTCLTATSG SDTFMFYNTG RPISGTWGSG ADRFFTSGSG FVRRLSMPDA
SLQICPEPKA PNADWRYSAS LRAGVQSSVH MEESSVMQGA QGMLVQNWPT VSSAADGEGG
GELSPPVGAG VNSNSWHFRY GAGPGYGPPQ PLKPGEIPPE AFIIPGSPAI ISIRHDAGPV
DDKGDFISFG KKEEAKKKKK KKKDKKDKKD KGKDDGGEE
//
