ID A0A3B4YLS8_SERLL Unreviewed; 946 AA.
AC A0A3B4YLS8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Sodium/calcium exchanger 1-like {ECO:0000313|Ensembl:ENSSLDP00000023779.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000023779.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000023779.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR AlphaFoldDB; A0A3B4YLS8; -.
DR STRING; 1841481.ENSSLDP00000023779; -.
DR Ensembl; ENSSLDT00000024542.1; ENSSLDP00000023779.1; ENSSLDG00000018536.1.
DR GeneTree; ENSGT00940000164137; -.
DR OrthoDB; 462435at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0042044; P:fluid transport; IEA:Ensembl.
DR GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878:SF73; NCX4A; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..946
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017231346"
FT TRANSMEM 76..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 918..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 404..503
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 546..645
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 946 AA; 104222 MW; 2F8A591E5F8DA9C2 CRC64;
MLLHKRILNC SPPVSPCMFM SLLLVLLPGV THFSQGSAGH EDAGSAAGNC SSDNNCSEGV
VLPMWNPQNP AVGDKVARAI VYFAALIYMF LGMSIIADRF MSSIEVITSQ EKEITIKKPN
GETTTTTVRI WNETVSNLTL MALGSSAPEI LLSVIEVVGH NFESGSLGPS TIVGSAAFNM
FIIIAICVYV VPENETRKIK HLRVFFVTAA WSVFAYIWLY LILSVFSPGE VEVWEAVLTF
LFFPLCVLQA WIADRRLLFY KYVNKRYRAD KTRGIIIESE GDAMFTKMDL EMDGQGVNSH
THPKEALDGM LEGVEEGGGM SAEQDQEEEA RREMARTLKD LKQRHPEKDM EQLIEMANYQ
VLVQQQKSRA FYRIQATRMM IGAGNILKKH AADQARKVVS CHEASGQEED PNTIYLQFDP
SHYQCFENCG SLKLSVSRHG GESGCTVKVD YRTEDGTANA GSDYEFAEGT LVFKPGETTK
EFTVGVIDDD IFEEDEHFYV RLSNPRIVHR AEVSVLEPSS ITSSNSTVGI SSHVPPKAAL
GNAHTATVTI YDDDHAGIFT FENNSMRVSE SVGNMQVKVH RTSGARGKVA VPYHTAEGTA
KAGEDYEEVS GKLEFQNDET MKLLNVKIID DEEYEKNKTF TIVLEEPILL EVGQRHGDTN
DNKTVVGPED VSKMGCPCLG EHTKLEVVIE ESYEFKSTVD KLIKKTNLAL VVGSSSWREQ
FVSAVTVSAG DDDEEESGEE RLPSCFDYIM HFLTVFWKVL FAFVPPTEYW NGWACFFVSI
SLIGVLTAVT GDLASHFGCT VGLKDSVTAV VFVALGTSVP DTFASKVAAI QDQYADASIG
NVTGSNAVNV FLGIGVAWTI AAVYWQTKGK VFKVHPGSLA FSVTLFTIMA LLVVLVLLYR
RRASVSGGEL GGPRTAKLLS FFLFLSLWSI YILLASLEAY CHVPGF
//
