ID A0A3B4YMW5_SERLL Unreviewed; 1433 AA.
AC A0A3B4YMW5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSSLDP00000024124.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000024124.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000024124.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR STRING; 1841481.ENSSLDP00000024124; -.
DR Ensembl; ENSSLDT00000024891.1; ENSSLDP00000024124.1; ENSSLDG00000018742.1.
DR GeneTree; ENSGT00940000159011; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 429..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1013..1034
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1040..1062
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1069..1095
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1107..1127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1139..1164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 428..588
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1258..1275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1330
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1433 AA; 159499 MW; B43804A6A5788204 CRC64;
MASAANAPSE QENRDPDRPR VTRRNRGNYT RNTPLDLEYL QRPSYCDAGF ALEQISEGKA
TGRKAPLWLR AKFQRLLFRL GCYIQKNCGK FLVVGLMIFG AFAVGLRAAN LETDVEKLWV
EVGGRVNQEL KYTRQKIGEE AMFNPQLMIQ TPREEGANVL TVDALLQHLE SAIRASRVHV
YLYNRQWKLE HLCYKSGELV TETHFMDQII EKLHPCLIIT PLDCFWEGAK LQSGMVYLPG
KDPLQWTNFD PKDFLEDLRR ANFPVEAFED MLEKADVGHG YMDRPCLNPA DPDCPLTAPN
KNSTKPFDVA RTLSGGCHGL SRKYMHWQEE LIVGGTTKNG SGPLLSAQAL QTMFQLMTPK
QMFEHFRGYE EVSHINWNEE KAAAILEAWQ RRYSEAVLQS VAANSSQKVL SFTTTTLEDI
LKSFSDISVI RVASGYLLML AYACLTMLRW DCAKSQGAVG LAGVLLVTLS VAAGLGLCSL
LGISFNAATT QVLPFLALGV GVDDVFLLAH AFSETGQNKR IPFEDRTGEC LKRTGASVAL
TSISNVTAFF MAALIPIPAL RAFSLQAAVV VVFNFAMVLL IFPAILSMDL YRREDRRFDI
FCCFYSPCAN RVIQIEPQAY SSPPPSYSSH GFAQQTEITM QSTVQLRTEY DPRTQAFYTT
AEPRSQISVQ PINPAPTRTS STGQSPENNS STRDLLSQFG EASLGLRCLE PPCSRWTLAS
FAEKHYAPFL LQPTTKVVVI VLFLCLLGVS LYGTTQVRDG LELTDIVPRE TSEYDFIGAQ
FKFFSFYNMY VVTQRADYAQ KQPLLHQLHQ RFHTVRYVLK EDNGQLPRMW LHYFRDWLQG
LQQAFDKDWE AGRITLNSYR NGSDDGVLAY KLLVQTGRRD KPINFNQLTR QRLVDADGII
NPGAFYIYLT AWVSNDPVAY AASQANIRPH PPEWLHDRTD SMPETRLSIP AAEPIEYAQF
PFYLNGLRET PQFVEAIESV RAICSNYSRQ GLPSYPNGYP FLFWEQYVSL RHWLLLSISV
VLACTFLVCA LFLLNPWTAG IIVLVLSLMT VELFGFMGLM GIKLSAVPVV ILIASVGIGV
EFTVHVALAF LTAIGDRHKR AVLALEHMFA PVLDGAFSTL LGVLMLAGSE FDFIVRYFFA
VLAILTVLGV LNGLVLLPVL LSYFGPYPEV SPVDGRSRLP TPSPEAPPHV VHFSVRPHHT
TGATTTTSGA ASDSSDSEYS SNTTVSGISQ ELQNYNLPSR RGPPRAEEQQ YHLQTSRGRA
ARPEEERRAG SGRRRSARQP DPPAPPPARP RMDAFETATE AGGHYGSHGH REHSAGHRAR
SSHNPQPHHL PHHHPNPTPY CQPITTVTAS ASVTVAVHPA PLPSQSPPAS SYPGYTATDS
YCPSGPEVPE PAFQDPHVPL ETQLGARGVK VEAMELQDLE FEAAESSHGR RAS
//
