ID   A0A3B4YNT6_SERLL        Unreviewed;      1096 AA.
AC   A0A3B4YNT6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-2-like {ECO:0000313|Ensembl:ENSSLDP00000031357.1};
GN   Name=CACNA2D2 {ECO:0000313|Ensembl:ENSSLDP00000031357.1};
OS   Seriola lalandi dorsalis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000031357.1, ECO:0000313|Proteomes:UP000261360};
RN   [1] {ECO:0000313|Ensembl:ENSSLDP00000031357.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC       family. {ECO:0000256|ARBA:ARBA00007060}.
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DR   AlphaFoldDB; A0A3B4YNT6; -.
DR   STRING; 1841481.ENSSLDP00000031357; -.
DR   Ensembl; ENSSLDT00000032253.1; ENSSLDP00000031357.1; ENSSLDG00000024097.1.
DR   GeneTree; ENSGT00940000156238; -.
DR   OrthoDB; 2971287at2759; -.
DR   Proteomes; UP000261360; Unplaced.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   CDD; cd01463; vWA_VGCC_like; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013680; VDCC_a2/dsu.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166:SF68; CALCIUM CHANNEL, VOLTAGE-DEPENDENT, ALPHA 2_DELTA SUBUNIT 2 ISOFORM X1; 1.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   Pfam; PF08473; VGCC_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF08399; VWA_N; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..1096
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017177143"
FT   DOMAIN          259..439
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   COILED          86..117
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1096 AA;  124320 MW;  18AA6E68DE076E16 CRC64;
     MAIGKRSCSI VCLVSIQIIL IFSASWPGAA ALTFPQQYTI MHWARRIEQE IDRVFQQITG
     AQQLKGIYNE ERRRFSLVKN QPRKIVEKVA SDIERLLAKK RKALDRLASE AERLQREHLW
     QDGIKELDMA YYDSKAELDY YSMDGEGEVE NPSHIKLEFV YDPNFKNNVN YSYTAVQIPT
     DIYKGAPVIL NELNWTQALE KVFMENSRED PSLLWQAFGS ATGVTRYYPA TPWKAPDKID
     LYDVRRRPWY IQGASSPKDM VILVDVSGSV SGLTLKLIKA SVMEMLDTLS DDDYVNVARF
     NEKAEAVVPC FKHLVQANVR NKKIFKDAVQ QMQAKGTTDY KSGFHFAFNQ LLNKTNVPRA
     NCNKIIMLFT DGGEDRAQDV FMQYNWPNKT VRVFTFSVGQ HNYDVTPLQW IACTNKGYYF
     EIRSICAIRI NTQEYLDVLG RPMVLAGSDA KQVQWTNVYQ DALGLGMVVT GTLPVFNLTM
     DGNSQNQLIL GVMGVDVHLD EIKRLTPRYN LGANGYIFAI DPNGYLLLHP NLQPKLVNLP
     EPVTLDFLDA EVEDTNKEEI RRQMIDGRPG DMQVKTLIKS IDENYIDEVY RGYTWTPING
     TDYSLGLVLP PYNDYYIQAD LSDVMLQLQY MQSLLPSSFE SSGHVFLAPR EYCKRLHLSD
     NNTQFLQNFL SLILDISPES DECDQSLIHN LILDSRIIGQ LASRVWKNKD LNSYGFLAVF
     ASTDGGITRV FPNIAAELWE EDPEPFNSNY YRRSLDNRGY MFRAPPRSSL DDPVGAENGT
     LGILVSSAVE VNLGGKLLKP AVVGVKLDME AWVDKFKILA SNVSDSRQGS HKCGPSRSCE
     MDCEVNTDDL LCYLIDDGGF LVMSNQRDHW KKIGLFFGDV DPYLMHALYN NSIFSRRQSF
     HYQSACEPVS SSHTGAAPRG IFVPSIADIL SLAWWTSTVA WSVVQQLLYG LAYNSLLYQD
     DVLVEGFETK ESSCVTIQSQ FYFTNTTNSY NVLQDCGNCS RLFHAKRIEN TNLLFVVAET
     LPCSSCEIER LTQVRTEFQE ENPCEVLSNA RYRKGPTSCF DYSALENTSE CGRGHSLESS
     IGVLLFIQLI LPLFHL
//