ID A0A3B4YQ34_SERLL Unreviewed; 400 AA.
AC A0A3B4YQ34;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Inhibin beta A chain {ECO:0000256|ARBA:ARBA00014111};
DE AltName: Full=Activin beta-A chain {ECO:0000256|ARBA:ARBA00032434};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000031822.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000031822.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC secretion of follitropin by the pituitary gland. Inhibins/activins are
CC involved in regulating a number of diverse functions such as
CC hypothalamic and pituitary hormone secretion, gonadal hormone
CC secretion, germ cell development and maturation, erythroid
CC differentiation, insulin secretion, nerve cell survival, embryonic
CC axial development or bone growth, depending on their subunit
CC composition. Inhibins appear to oppose the functions of activins.
CC {ECO:0000256|ARBA:ARBA00002588}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3B4YQ34; -.
DR STRING; 1841481.ENSSLDP00000031822; -.
DR Ensembl; ENSSLDT00000032730.1; ENSSLDP00000031822.1; ENSSLDG00000024440.1.
DR GeneTree; ENSGT00940000157116; -.
DR OrthoDB; 3015718at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd19404; TGF_beta_INHBA; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000491; Inhibin_betaA.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF290; INHIBIN SUBUNIT BETA AB; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00670; INHIBINBA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..400
FT /note="Inhibin beta A chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017446562"
FT DOMAIN 281..400
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 108..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 44120 MW; 6F9D40143C53D20A CRC64;
MSSLLAVFFF MALSLLINAS SVVSPAPEVD KVPQLQEGAS SSVCPSCSLS QMRRNSTLPG
GQSDMVEAVK RHILNMLHLS ARPNLTQPVP RAALLNAIKK LHVGHVTEDG SVEIQEEGRG
SRTPTSPEPP SEIITFAEPG DSQNTVTFDI SKEGSGSSVV EQANIWIFLK MSKGNQAKGK
VTIRLLQLHH DNDEEERVSE KMVDTRRSGW HTLAIPRSVQ TLLDSGGRSL NLRVSCPLCA
EAGASPVLMP AKGEQAAGRD HSHRPFIMVV LQAQEEASQR RVKRGLECDG KIHICCKRQF
YVNFKDIGWN DWIIAPSGYH ANYCEGDCPN HMASLSGSSL SFHSTVINHY RMRGYGPFQN
IKSCCVPTKL RAMSMLYYNE EQKIIKKDIQ NMIVEECGCS
//