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Database: UniProt
Entry: A0A3B4YQ34_SERLL
LinkDB: A0A3B4YQ34_SERLL
Original site: A0A3B4YQ34_SERLL 
ID   A0A3B4YQ34_SERLL        Unreviewed;       400 AA.
AC   A0A3B4YQ34;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Inhibin beta A chain {ECO:0000256|ARBA:ARBA00014111};
DE   AltName: Full=Activin beta-A chain {ECO:0000256|ARBA:ARBA00032434};
OS   Seriola lalandi dorsalis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000031822.1, ECO:0000313|Proteomes:UP000261360};
RN   [1] {ECO:0000313|Ensembl:ENSSLDP00000031822.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC       secretion of follitropin by the pituitary gland. Inhibins/activins are
CC       involved in regulating a number of diverse functions such as
CC       hypothalamic and pituitary hormone secretion, gonadal hormone
CC       secretion, germ cell development and maturation, erythroid
CC       differentiation, insulin secretion, nerve cell survival, embryonic
CC       axial development or bone growth, depending on their subunit
CC       composition. Inhibins appear to oppose the functions of activins.
CC       {ECO:0000256|ARBA:ARBA00002588}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   AlphaFoldDB; A0A3B4YQ34; -.
DR   STRING; 1841481.ENSSLDP00000031822; -.
DR   Ensembl; ENSSLDT00000032730.1; ENSSLDP00000031822.1; ENSSLDG00000024440.1.
DR   GeneTree; ENSGT00940000157116; -.
DR   OrthoDB; 3015718at2759; -.
DR   Proteomes; UP000261360; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   CDD; cd19404; TGF_beta_INHBA; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR000491; Inhibin_betaA.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF290; INHIBIN SUBUNIT BETA AB; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   PRINTS; PR00670; INHIBINBA.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}; Hormone {ECO:0000256|ARBA:ARBA00022702};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..400
FT                   /note="Inhibin beta A chain"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017446562"
FT   DOMAIN          281..400
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          108..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   400 AA;  44120 MW;  6F9D40143C53D20A CRC64;
     MSSLLAVFFF MALSLLINAS SVVSPAPEVD KVPQLQEGAS SSVCPSCSLS QMRRNSTLPG
     GQSDMVEAVK RHILNMLHLS ARPNLTQPVP RAALLNAIKK LHVGHVTEDG SVEIQEEGRG
     SRTPTSPEPP SEIITFAEPG DSQNTVTFDI SKEGSGSSVV EQANIWIFLK MSKGNQAKGK
     VTIRLLQLHH DNDEEERVSE KMVDTRRSGW HTLAIPRSVQ TLLDSGGRSL NLRVSCPLCA
     EAGASPVLMP AKGEQAAGRD HSHRPFIMVV LQAQEEASQR RVKRGLECDG KIHICCKRQF
     YVNFKDIGWN DWIIAPSGYH ANYCEGDCPN HMASLSGSSL SFHSTVINHY RMRGYGPFQN
     IKSCCVPTKL RAMSMLYYNE EQKIIKKDIQ NMIVEECGCS
//
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