ID   A0A3B4YRU4_SERLL        Unreviewed;       976 AA.
AC   A0A3B4YRU4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=DENN domain containing 2A {ECO:0000313|Ensembl:ENSSLDP00000030941.1};
GN   Name=DENND2A {ECO:0000313|Ensembl:ENSSLDP00000030941.1};
OS   Seriola lalandi dorsalis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000030941.1, ECO:0000313|Proteomes:UP000261360};
RN   [1] {ECO:0000313|Ensembl:ENSSLDP00000030941.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4YRU4; -.
DR   Ensembl; ENSSLDT00000031831.1; ENSSLDP00000030941.1; ENSSLDG00000023765.1.
DR   GeneTree; ENSGT00950000182931; -.
DR   Proteomes; UP000261360; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR15288:SF3; DENN DOMAIN-CONTAINING PROTEIN 2A; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT   DOMAIN          541..936
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          1..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          376..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          411..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          470..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..263
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..299
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..314
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..508
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   976 AA;  109955 MW;  A356AE6CD3257EC6 CRC64;
     SKRPLSPLLS LSDSPGPPDT MLAHRRASNT TDPRTSNMEN GLCGKLNHSK SPAAVKSASI
     RDKISQWEGK KEPAQLTSTG TCPLSTTQKE VETVRKKESK VSEVQRTDSK RFVSWDRQDS
     GKENVGKLGD SRPKSPEGPT NKDREVILER GFRASKPTEQ PLDKKTVLTH VKKLEKATKE
     VPDRPSLAFP GNYFCPPSKE EVEETEKRAG EPIFGSFDVP RPGGSRRRRE GDPENVYSEP
     GAPSINPLPK PQRTFQHHTP PATPASGAGS GKGKRNLPPL PSIPPPPLPT CPPPGVCRRP
     WADKPRDSSN RKSYEFEDLL QSSTESCRVD WYAQSRLGLT RTLSEENVYE DIIDPPSKEN
     PYEDIELERS CLGSKCVSPA SSSPVPDTPT KLSSKPGFFR QNSERRSFKL LELRKTGRDT
     GVSSPSRVSP PSTPSSPDDT PCLSGDPYNR RRRKIPKMVL KINGIFEARR GKKRMKRVSQ
     STESSSGRVT DENSESESDT EEKLKAHSQR LVSVQSMLRQ TGRYRTLERD LMELQERKLF
     EYFIVVALHK TKAGVPYLPE VTQQFPLKLE RSFKFMRETE DQLKVIPQFC FPDAKDWAPV
     DNFPSETFSF VLTGEDGSRR FGYCRRLLPS GKGRRLPEVY CIVSRLGCFD LFSKILDEVE
     KRRAISPALV QPFMRGIMEA PFPAPGRTIT VKNFLPGSGT EVIELCRPSD SRLEHVDFEC
     LFSSLSLRLL LRVFASLLLE RRVIFTADKL STLSQCCHAV VALLYPFTWQ HTYIPVLPPS
     MLDIVCTPTP FIVGLLSSSL PRLKELPIEE VLVVDLGNSR FLRQLDDEDS ILPHKLQAAL
     EHVLDKRREL ACEKGDLPND SSCLSTVVSE AFVRFFVEMV GHYSLFMGGA EREDESREAF
     RKAVTSKSLR RFLEVFMETQ MFTGFIQERE LRRQGLRGLF EVRAQEYLDS LPGSEQRGVN
     KFLKGLGNKM KFLSKK
//