ID A0A3B4YTG9_SERLL Unreviewed; 834 AA.
AC A0A3B4YTG9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Circadian locomoter output cycles protein kaput {ECO:0000256|ARBA:ARBA00040572};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000031531.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000031531.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
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DR AlphaFoldDB; A0A3B4YTG9; -.
DR STRING; 1841481.ENSSLDP00000031531; -.
DR Ensembl; ENSSLDT00000032430.1; ENSSLDP00000031531.1; ENSSLDG00000024209.1.
DR GeneTree; ENSGT00940000160744; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR PANTHER; PTHR46055:SF2; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 34..84
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 107..155
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 285..332
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 390..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 498..546
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 400..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 95378 MW; 3377FA2193D13DD5 CRC64;
FIFNVSCLNT FFSSFRDDCS IFDGLMEEDE KDKAKRVSRN KSEKKRRDQF NVLIKELGTM
LPGNTRKMDK STILQKSIDF LCKHKEIAAQ SESSEIRQDW KPPFLSNEEF TQLMLEALDG
FFIAIMTDGN ILYVSESVTS LLEHLPADLV DQNLLNFLPV GEHSDVYKAL STHPTDPENL
SSDYLKTKNH MEFCCHMLRG AIDPKEPPVY EYVKFIGNFK SLNNVPNVTR NGLAGVLQRS
LQPAFDDQVC FVATVRLAKP QFIKEMCTVE EPNEEFTSRH SLEWKFLFLD HRAPPIIGYL
PFEVLGTSGY DYYHVDDLET LARCHEHLMQ YGKGKSCYYR FLTKGQQWIW LQTHYYITYH
QWNSRPEFIV CTHTVVSYAE VRAEQRRELG IEESNPEVAV DKSQDSGSES QLNTSSLKEA
LERFDHSRTP STSSRSSRKS SSHVSDNTST ASKLHMDTAT PPRQSLASTM EMTSQRRSSI
SSQVRLLTYY FSLHPQPVME FSAQVNAMQH LKEQLEQRTR MIQANIQRQQ EELRHIQEQL
QRVQGQGIQM LLQQQGGAMN VQLPQVGSVQ QTSTLTSQVQ QTTINPVHSG TQQLTIQQQP
QRQSQQPAQA QSQTQGSVST PLYNTMMISQ PGQPNVLQIS TSLPQNNTPQ GTTVATFTQD
RQIRFPAGQQ LVTKLVTAPM ACGAVMVPTS MFMGQVVTAY NPFGGQQRDL LNQVLTVSYF
NSLALFFCQG TRLLHSNQST QLILQAAFPL QQQGTFTQAT HQQQTQQQQQ QQQQQQQQQQ
QQQQQQQQRQ QQQQQQQQQQ SHHQRHQQQL KPQPQKQQKA PTSHRTDSVS SQPQ
//
