ID A0A3B4YUM7_SERLL Unreviewed; 386 AA.
AC A0A3B4YUM7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF {ECO:0000256|PIRNR:PIRNR037866};
GN Name=NHERF2 {ECO:0000313|Ensembl:ENSSLDP00000033512.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000033512.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000033512.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Scaffold protein that connects plasma membrane proteins with
CC members of the ezrin/moesin/radixin family and thereby helps to link
CC them to the actin cytoskeleton and to regulate their surface
CC expression. {ECO:0000256|PIRNR:PIRNR037866}.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184,
CC ECO:0000256|PIRNR:PIRNR037866}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B4YUM7; -.
DR STRING; 1841481.ENSSLDP00000033512; -.
DR Ensembl; ENSSLDT00000034444.1; ENSSLDP00000033512.1; ENSSLDG00000025636.1.
DR GeneTree; ENSGT00950000182849; -.
DR OrthoDB; 2914289at2759; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 2.
DR InterPro; IPR015098; EBP50_C.
DR InterPro; IPR017300; NHERF-1/NHERF-2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14191:SF4; NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2; 1.
DR PANTHER; PTHR14191; PDZ DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF09007; EBP50_C; 1.
DR Pfam; PF00595; PDZ; 2.
DR PIRSF; PIRSF037866; EBP50; 1.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR PROSITE; PS50106; PDZ; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|PIRNR:PIRNR037866}.
FT DOMAIN 9..89
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 194..274
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 108..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 42080 MW; A3432B683E6A96F3 CRC64;
MASERKPRLC VMTKGENGYG FHLHGEKGKS GQFIRKVESG SPAEESGLRP GDRVVAVNGV
NVEKETHHQV VQRIKAVDHE TRLLVVDHET HESLRSLRLT ATEEMAILGT GHPSSSSPPA
SPSPSPSLVP SSPSKKRENG SVSKQPATLS SQVQKPTRRS PSKAAKKEAQ AEAHTQAQSQ
SRPQVDPSNL VPRLCHLVRS ETGYGFNLHS DRSRPGQYIR SLDPGSPADR AGLQPQDRLI
EVNGVNIEGM RHAEVVAFIK KGGDETWLLV VDPDTDEHFK RRGVIPTVGH LKDYDGPSIS
NGSPSPQING SSTTQSIRST RSDLSSQGNS TQLADDEGGR LSDPFAEMGL TLSATAAEEK
MKVHAKEKRK APQMDWMKKY ELFSNF
//
