ID A0A3B4YVL8_SERLL Unreviewed; 1619 AA.
AC A0A3B4YVL8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=SH3 and multiple ankyrin repeat domains protein 1-like {ECO:0000313|Ensembl:ENSSLDP00000026794.1};
GN Name=SHANK1 {ECO:0000313|Ensembl:ENSSLDP00000026794.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000026794.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000026794.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR Ensembl; ENSSLDT00000027618.1; ENSSLDP00000026794.1; ENSSLDG00000018921.1.
DR GeneTree; ENSGT00940000153561; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF3; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT REPEAT 198..231
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 232..264
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 332..364
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 475..534
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 576..670
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1556..1619
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 730..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1445..1524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..762
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..898
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1140
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1253
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1481
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1619 AA; 176898 MW; 5C87A37D5A9C929D CRC64;
MSNQVLLHHQ VANKQQHHFI AANQQPHHLG LNVLQKRRAL MERSMTTVAP LEDTFLTMMV
FRIGIPDIKQ TRCLQFDQDC TVWNAKQQII CSLSESLWDA YNYGLFQPAG DGRDAKFLEE
ERALQDYSQS FEKGVPYLEF RYKTRVYKQT NLDEKALAKL STKASLKKFL DYIQTGAIEK
MAKVLDKGLD PNFHDPDSGE TPLSVAVQSG LPVEGIRVLV QGGAHLDFRS RDGFTPVHKA
VRAHNHAGLL ALLSFGASPD YKDRCGLTPL YHTVLAGGDT SCCETLLYYR ARLGTRDENG
WDESHQACQN GFAQHLEHLL FYGADTTSLN ASGNTALHIS ALYNKESCVR VLLYRGANRE
AKNKHGQTPF QLAVMSGHFE LGEIIKNHKD SDIGKFSIPS TCPFFVPFEI CHDICPYNLS
FPLTIYLISP SISSLCNTIL SHSFVRDSLS PSLSLCSATS AGSGGGQMKR MYSAVPGRVY
VATRAHSASG DRELSLNKGD KVKVLSVGEG GYWEGTVKGR TGWFPSDCVE EVAGFSKDNR
SETRSEKAKR KLFRNVTVGA YDGTDGPSDY IIKEKTVLLQ KKDNEGFGFV LRGAKAQTPI
EEFTPTPAFP ALQYLESVDE GGVAWRAGLR MGDFLIEVNG QNVVKVGHRQ VVNMIRQGGN
SLMVKVVMVA RNPELEDTAR KRAPQQTKRL TPPAIALRSK SMTSELEDMG VTEEERQYLH
PPAMKLARSL SVPGPEEIPP PPNTSAPEPP LSAGPHPVRG PAMPIPPVSQ AHYQLHSQPG
HPTQAGWERG GPGGMNQQVM VPTLRRQSEG LCVREPEAPR RGGGKMGGLR RGYSSATPPT
SAKPKAQQAP QHHPHIANRE QGGGVGRGAA RRGGRGALMK QSKVEDGVRQ HRSKGGAAKE
KSSIPIPTII VKAPSTSSSG RSSQGSSMEA EPTQDQNLEN LDYTSTYGSA FGGGGARRDR
ERLRDMRRKS ASFFLSSEED IQGEAGGGGV VEGGGALGTR IQPLQAFGLP EYSSPILSQD
GQPKSAPSMY GTQPATTFIH PLTGKVLDPS SPLGLALAAR ERALKDDRRT RREDRHFGRQ
LSTVGAFPTP VQTPTPSLFP ATVTKDITFG RRREREKEMY DSRPAPPIQP PPPPAQPAPR
RPSFLQMEST TNTSYIPQYT VPTAPAQTHE AMGDVRAGGG GLGLMVLPPP APSIDADDEF
VFADPLPPPL QFANGKNERV QEFPQRHQHP SQHSAAVAPP PPPPLPSAKP SNVPQPSPQG
DAVVDSGIEE LDSHSSSDHH LEMLGLSGLR GERGGVGGDG RGGEGERGSE HQDPCTTYSG
GQTFEVHSAK LANPVFPKMT HYKEGGGRGQ SVALRRQNST NPAPLQLQRQ SGGLQRGGMV
LESRRLHSPL SGVKASIINE LSSKLQQMSS MKSMDDWSHT PKSPTMHRFH RSKFRRQTFD
FQCSPTKEMR SSVSRRRAPS PLIYNTEQPN PTPPRPSSLP ILPSTPVYNN PFDFPGPLTP
PSPGLPLGDT YKAPNPLLVS PSSPMHLPPS PSCLNYPHLT PPPPAKPFAV KPLPYWTKYD
VADWLAYLNL GEHRERFIDN EIDGSHLPSL TKDDFLDLGV TRVGHRMNIE RALKKLTDR
//
